Significance of 8-hydroxy-2'-deoxyguanosine levels in patients with chronic renal failure
| Autor: | Junko Kasahara, Ai Yano, Kiyohito Nanba, Shigeru Akagi, Ai Sarai, Yoshio Nagake, Haruo Ichikawa, Takashi Kihara, Hirofumi Makino, Kazushi Nakao, Hisanori Morimoto |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Urinary system Renal function medicine.disease_cause chemistry.chemical_compound In vivo Internal medicine Humans Medicine Deoxyguanosine Creatinine business.industry 8-Hydroxy-2'-deoxyguanosine General Medicine Middle Aged Endocrinology chemistry 8-Hydroxy-2'-Deoxyguanosine Nephrology Kidney Failure Chronic Chronic renal failure Female business Oxidative stress |
| Zdroj: | Nephrology. 8:192-195 |
| ISSN: | 1440-1797 1320-5358 |
| DOI: | 10.1046/j.1440-1797.2003.00163.x |
| Popis: | The aim of this study was to determine the significance of 8-hydroxy-2'-deoxyguanosine (8-OHdG), which is known as a marker of oxidative stress in vivo, in patients with chronic renal failure (CRF). Fifty-one non-dialysed CRF patients (29 men and 22 women; mean +/- SD age, 57.8 +/- 12.8 years) who were under dietary therapy for at least 6 months were enrolled in the study. Both serum and urinary 8-OHdG levels were measured by using high-sensitive enzyme-linked immunosorbent assay (ELISA) kits. We examined the relationship between 8-OHdG levels and clinical indices in patients with CRF. As a result, the serum 8-OHdG level was strongly correlated with serum levels of urea nitrogen (UN; r = 0.58; P < 0.0001), creatinine (Cr; r = 0.53; P < 0.0001), and beta2-microglobulin (beta2-MG; r = 0.54; P < 0.0001). Furthermore, the serum 8-OHdG level was inversely correlated with creatinine clearance (Ccr; r = -0.54; P < 0.0001). In contrast, urinary 8-OHdG level was not correlated with any of the clinical parameters. This is the first report of 8-OHdG level determination in patients with CRF. It is suggested that serum 8-OHdG level is not sufficient as a marker of oxidative damage in patients with CRF, and it should be corrected according to the residual renal function to estimate the accurate degree of oxidative stress. |
| Databáze: | OpenAIRE |
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