Tight junction proteins in gastrointestinal and liver disease

Autor: Punita Dhawan, Mirjam B. Zeisel, Thomas F. Baumert
Přispěvatelé: Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Interactions Virus-Hôte et Maladies Hépatiques, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Virologie, Université de Strasbourg (UNISTRA), Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, University of Nebraska System-University of Nebraska System, Buffet Cancer Center [Omaha, NE, USA], VA Nebraska-Western Iowa Health Care System [Omaha, NE, USA], Pôle hépato-digestif [Strasbourg], Nouvel Hôpital Civil, Hospices Civils de Strasbourg-Institut Hospitalo-Universitaire de strasbourg, ARC, Paris and Institut Hospitalo-Universitaire, Strasbourg (TheraHCC IHUARC IHU201301187), the European Union (ERC-AdG-HEPCIR, ERC-PoC-2016-PRELICAN, EU H2020-667273-HEPCAR, U Strasbourg Foundation HEPKIN), the National Institutes of Health (NCI 1R21CA209940-01A1, NIAID R03AI131066, NIAID 5U19AI123862-02), the Institut Universitaire de France (IUF), the IdEx Program of the University of Strasbourg, the Impulsion Program of the IDEXLYON, BX002086 (VA merit), CA216746 (NIH/NCI) and a pilot project award from Fred and Pamela Buffet Cancer Center, which is funded by a National Cancer Institute Cancer Center Support Grant under award number P30 CA036727. This work has been published under the framework of the LABEX ANR-10-LABX-0028_HEPSYS and benefits from funding from the state managed by the French National Research Agency as part of the investments for the future programme., ANR-10-LABX-0028,HepSys,Functional genomics of viral hepatitis and liver disease(2010), European Project: 667273,H2020,H2020-PHC-2015-two-stage,HEP-CAR(2016), European Project: 671231,H2020,ERC-2014-ADG,HEPCIR(2016), European Project: 755460,PRELICAN, Zeisel, Mirjam, Mechanisms underlying hepatocellular carcinoma pathogenesis and impact of co-morbidities. - HEP-CAR - - H20202016-01-01 - 2019-12-31 - 667273 - VALID, Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Rok vydání: 2018
Předmět:
hepatitis C virus
0301 basic medicine
Carcinoma
Hepatocellular
Gastrointestinal Diseases
tight junction
colorectal cancer
Disease
Sciences du Vivant [q-bio]/Médecine humaine et pathologie
Biology
Antiviral Agents
Article
Tight Junctions
Pathogenesis
03 medical and health sciences
Liver disease
0302 clinical medicine
medicine
Humans
Molecular Targeted Therapy
Receptor
Integral membrane protein
Gastrointestinal Neoplasms
colorectal
Regulation of gene expression
Tight Junction Proteins
Tight junction
Liver Diseases
Liver Neoplasms
Gastroenterology
Cancer
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
hepatocellular carcinoma
medicine.disease
[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
3. Good health
Gastrointestinal Tract
Cell Transformation
Neoplastic
030104 developmental biology
Liver
Claudins
Cancer research
claudin-1
030211 gastroenterology & hepatology
hepatitis C
Zdroj: Gut
Gut, 2018, Epub ahead of print. ⟨10.1136/gutjnl-2018-316906⟩
Gut, In press, Epub ahead of print. ⟨10.1136/gutjnl-2018-316906⟩
Gut, BMJ Publishing Group, In press, Epub ahead of print. ⟨10.1136/gutjnl-2018-316906⟩
ISSN: 1468-3288
0017-5749
DOI: 10.1136/gutjnl-2018-316906
Popis: Over the past two decades a growing body of evidence has demonstrated an important role of tight junction (TJ) proteins in the physiology and disease biology of gastrointestinal (GI) and liver disease. On one side, TJ proteins exert their functional role as integral proteins of TJs in forming barriers in the gut and the liver. Furthermore, TJ proteins can also be expressed outside TJs where they play important functional roles in signaling, trafficking and regulation of gene expression. A hallmark of TJ proteins in disease biology is their functional role in epithelial-to-mesenchymal transition. A causative role of TJ proteins has been established in the pathogenesis of colorectal cancer and gastric cancer. Among the best characterized roles of TJ proteins in liver disease biology is their function as cell entry receptors for hepatitis C virus – one of the most common causes of hepatocellular carcinoma. At the same time TJ proteins are emerging as targets for novel therapeutic approaches for GI and liver disease. Here we review our current knowledge of the role of TJ proteins in the pathogenesis of GI and liver disease biology and discuss their potential as therapeutic targets.
Databáze: OpenAIRE
Externí odkaz: