Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis
| Autor: | Tzu Yu Hsu, Niall W. Duncan, Hsin Chien Lee, Vuong Truong, Paul Z. Cheng, Timothy Joseph Lane |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Glutamine Neuroscience (miscellaneous) Glutamic Acid gamma-Aminobutyric acid 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Prefrontal cortex gamma-Aminobutyric Acid Depressive Disorder Major business.industry Glutamate receptor medicine.disease Magnetic Resonance Imaging 030227 psychiatry Cortex (botany) Psychiatry and Mental health Endocrinology Visual cortex medicine.anatomical_structure Mood disorders nervous system Major depressive disorder business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Psychiatry Research: Neuroimaging |
| Popis: | The neurotransmitters GABA and glutamate have been suggested to play a role in Major Depressive Disorder (MDD) through an imbalance between cortical inhibition and excitation. This effect has been highlighted in higher brain areas, such as the prefrontal cortex, but has also been posited in basic sensory cortices. Based on this, magnetic resonance spectroscopy (MRS) was used to investigate potential changes to GABA+ and glutamate+glutamine (Glx) concentrations within the occipital cortex in MDD patients (n = 25) and healthy controls (n = 25). No difference in occipital GABA+ or Glx concentrations, nor in the GABA+/Glx ratio, was found between groups. An analysis of an extended MDD patient and unmatched control dataset (n = 90) found no correlation between metabolite concentrations and depressive symptoms. These results were integrated with prior studies through metabolite-specific meta-analyses, revealing no difference in occipital GABA and Glx concentrations between patients and controls. An effect of publication year on GABA group differences was found, suggesting that previously reported results may have been artifacts of measurement accuracy. Taken together, our results suggest that, contrary to some prior reports, MRS measurements of occipital GABA and Glx do not differ between MDD patients and controls. |
| Databáze: | OpenAIRE |
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