Comparative histological analysis of anterior vaginal wall in women with pelvic organ prolapse or control subjects. A pilot study
| Autor: | X. Monrozies, Pierre Marès, Renaud de Tayrac, Philippe-Jean Bousquet, W. Badiou, Guillaume Granier |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Biopsy
Urology medicine.medical_treatment Connective tissue Pilot Projects Hysterectomy Severity of Illness Index Vaginal wall Extracellular matrix Smooth muscle Uterine Prolapse Humans Medicine Trichrome stain Aged Pelvic organ business.industry Obstetrics and Gynecology Muscle Smooth Anatomy Middle Aged Control subjects Immunohistochemistry Actins medicine.anatomical_structure Vagina Female business |
| Zdroj: | International Urogynecology Journal. 19:723-729 |
| ISSN: | 1433-3023 0937-3462 |
| DOI: | 10.1007/s00192-007-0516-4 |
| Popis: | The purpose of this study was to compare smooth muscle content of anterior vaginal wall in women with pelvic organ prolapse (POP) and control subjects. Specimens were taken in the midline from the apex of anterior vaginal cuff from eleven women with POP and eight control subjects operated for hysterectomy without prolapse. Masson's trichrome stain was used to determine the distribution of collagen in the extracellular matrix of the vaginal muscularis and to quantify the collagen in area of interest. Slides of alpha smooth muscle actin were detected using antibodies. Morphometric analysis was used to compare and to quantify the smooth muscle content of the vaginal muscularis. Fractional area of nonvascular vaginal smooth muscle of women with POP was significantly decreased in comparison to control subjects (41.9 vs 61.9%, p = 0.005). Fractional area of connective tissue was significantly increased (56.8 vs 35%, p = 0.004). Fractional area of blood vessels was similar (2.2 vs 3.4%, p = 0.20). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink