Correlation between urinary nicotine, cotinine and self-reported smoking status among educated young adults
| Autor: | Ahmad Shalihin Mohd Samin, Razak Lajis, Ahmed Ibrahim Fathelrahman, Gam Lay Harn, Che Nin Man, Rahmat Awang, Nurulain Abdullah Bayanuddin, Maizurah Omar |
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| Rok vydání: | 2009 |
| Předmět: |
Pharmacology
medicine.medical_specialty business.industry Health Toxicology and Mutagenesis Urinary system General Medicine Urine Toxicology Tobacco smoke Correlation Nicotine chemistry.chemical_compound chemistry Environmental health Epidemiology medicine Young adult Cotinine business medicine.drug |
| Zdroj: | Environmental Toxicology and Pharmacology. 28:92-96 |
| ISSN: | 1382-6689 |
| DOI: | 10.1016/j.etap.2009.03.003 |
| Popis: | The objective of this study was to correlate, differentiate and validate the self-reported smoking status of educated young adults with urinary biomarkers (i.e. nicotine and cotinine). Freshmen students were recruited on voluntary basis. They filled-up self-administered questionnaire and their urine samples were collected for analysis. The urinary nicotine (UN) and cotinine (UC) were measured by gas chromatograph–mass spectrometry. Smokers, non-smokers and ex-smokers were found to be both significantly correlated and different in their UN and UC levels. UC level of 25 ng/ml was the optimal cut-off to differentiate smokers from non-smokers. Using this cut-off value, the prevalence of smoking among the students was found to be higher (15.4%) than the self-reported data (14.3%). UC is useful in validating individual recent smoking history and the cut-off could serve as a marker for assessing the clinical impact of smoking and environmental tobacco smoke (ETS) exposure on human health. |
| Databáze: | OpenAIRE |
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