A high-density electroencephalography study reveals abnormal sleep homeostasis in patients with rapid eye movement sleep behavior disorder

Autor: Ruth M. Benca, David T. Plante, Giulio Tononi, Keith P. Nakamura, Stephanie G. Jones, Brady A. Riedner, Amandine Valomon, Mélanie Boly
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Adult
Male
medicine.medical_specialty
Polysomnography
Science
Rapid eye movement sleep
REM Sleep Behavior Disorder
Audiology
Electroencephalography
Neurodegenerative
Non-rapid eye movement sleep
Article
03 medical and health sciences
0302 clinical medicine
Clinical Research
Behavioral and Social Science
mental disorders
medicine
Tonic (music)
Humans
Homeostasis
Beta Rhythm
Multidisciplinary
medicine.diagnostic_test
business.industry
musculoskeletal
neural
and ocular physiology
Neurosciences
Eye movement
Brain
Cognition
Middle Aged
Sleep in non-human animals
Brain Disorders
030104 developmental biology
Mental Health
Case-Control Studies
Medicine
Female
Sleep Stages
business
Sleep
Sleep Research
030217 neurology & neurosurgery
Neurological disorders
psychological phenomena and processes
Zdroj: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific reports, vol 11, iss 1
Scientific Reports
ISSN: 2045-2322
Popis: Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by disrupting motor enactments during REM sleep, but also cognitive impairments across several domains. In addition to REM sleep abnormalities, we hypothesized that RBD patients may also display EEG abnormalities during NREM sleep. We collected all-night recordings with 256-channel high-density EEG in nine RBD patients, predominantly early-onset medicated individuals, nine sex- and age- matched healthy controls, and nine additional controls with matched medications and comorbidities. Power spectra in delta to gamma frequency bands were compared during both REM and NREM sleep, between phasic and tonic REM sleep, and between the first versus last cycle of NREM sleep. Controls, but not RBD patients, displayed a decrease in beta power during phasic compared to tonic REM sleep. Compared to controls, RBD patients displayed a reduced decline in SWA from early to late NREM sleep. Overnight changes in the distribution of the amplitude of slow waves were also reduced in RBD patients. Without suppression of beta rhythms during phasic REM sleep, RBD patients might demonstrate heightened cortical arousal, favoring the emergence of behavioral episodes. A blunted difference between REM sleep sub-stages may constitute a sensitive biomarker for RBD. Moreover, reduced overnight decline in SWA suggests a reduced capacity for synaptic plasticity in RBD patients, which may favor progression towards neurodegenerative diseases.
Databáze: OpenAIRE
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