Increased Salivary Levels of 8-Hydroxydeoxyguanosine May Be a Marker for Disease Activity for Periodontitis

Autor: Sezer, Ufuk, Çiçek, Yasin, Çanakçi, Cenk Fatih
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Disease Markers, Vol 32, Iss 3, Pp 165-172 (2012)
Disease markers
ISSN: 1875-8630
0278-0240
Popis: Background: 8-hydroxydeoxyguanosine (8-OHdG) is commonly used as a marker to evaluate oxidative DNA damage in disorders including chronic inflammatory diseases such as inflammatory periodontal pathologies. In the current study we hypothesized that the level of 8-OHdG in saliva increases by the periodontal destruction severity determined by clinical parameters as clinical attachment level (CAL).Materials and methods: A cross-sectional study was conducted on a sum of 60 age gender balanced; chronic periodontitis (CP) (n= 20), chronic gingivitis (CG) (n= 20) and healthy (H) (n= 20) individuals. Clinical periodontal parameters and salivary 8-OHdG levels were evaluated.Results: The mean 8-OHdG level in the saliva of the CP group was significantly higher than H and CG groups (p< 0.001). Statistically significant correlation was only observed between the salivary levels of 8-OHdG and age (p< 0.05), probing depth (PD) and CAL (p< 0.001) in CP group. However, when CP patients were classified according to their CAL levels (CAL≥ 3 mm (n= 11) and CALn= 9)) statistically significant correlation was only observed between the salivary levels of 8-OHdG and CAL≥ 3 mm patients (p< 0.001).Conclusion: We suggest that elevated salivary levels of 8-OHdG may be a marker for disease activity and it may reflect indirectly disease severity parameters such as CAL.
Databáze: OpenAIRE
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