Accelerated Telomere Attrition Is Associated with Relative Household Income, Diet and Inflammation in the pSoBid Cohort

Autor: Alex McConnachie, Chris J. Packard, Agnes McGinty, Yoga N. Velupillai, G. David Batty, Paul C. D. Johnson, Liane M. McGlynn, Paul G. Shiels, Kevin A. Deans, Alan MacIntyre, Carol Tannahill, Naveed Sattar, Keith Millar, Harry Burns, Ian Ford, Jennifer S. McLean, Jonathan Cavanagh
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Gerontology
Male
Aging
Anatomy and Physiology
Non-Clinical Medicine
Epidemiology
lcsh:Medicine
Disease
biolgoical ageing
Cohort Studies
chemistry.chemical_compound
Molecular Cell Biology
lcsh:Science
Family Characteristics
Multidisciplinary
Chromosome Biology
Epidemiology of Aging
Genomics
Middle Aged
Telomere
Socioeconomic Aspects of Health
Telomeres
Cohort
Income
Medicine
Regression Analysis
Female
Public Health
Behavioral and Social Aspects of Health
Cohort study
Research Article
Adult
socio-economic status
Diabetes mellitus
medicine
Humans
poor diet
Socioeconomic status
Biology
Life Style
Inflammation
Evolutionary Biology
Population Biology
Cholesterol
business.industry
Interleukin-6
lcsh:R
medicine.disease
Diet
Biomarker Epidemiology
chemistry
Ageing
Housing
lcsh:Q
business
Physiological Processes
Organism Development
Biomarkers
Demography
Developmental Biology
Zdroj: PLoS ONE
PLoS ONE, Vol 6, Iss 7, p e22521 (2011)
ISSN: 1932-6203
Popis: peer-reviewed Background: It has previously been hypothesized that lower socio-economic status can accelerate biological ageing, and predispose to early onset of disease. This study investigated the association of socio-economic and lifestyle factors, as well as traditional and novel risk factors, with biological-ageing, as measured by telomere length, in a Glasgow based cohort that included individuals with extreme socio-economic differences. Methods: A total of 382 blood samples from the pSoBid study were available for telomere analysis. For each participant, data was available for socio-economic status factors, biochemical parameters and dietary intake. Statistical analyses were undertaken to investigate the association between telomere lengths and these aforementioned parameters. Results: The rate of age-related telomere attrition was significantly associated with low relative income, housing tenure and poor diet. Notably, telomere length was positively associated with LDL and total cholesterol levels, but inversely correlated to circulating IL-6. Conclusions: These data suggest lower socio-economic status and poor diet are relevant to accelerated biological ageing. They also suggest potential associations between elevated circulating IL-6, a measure known to predict cardiovascular disease and diabetes with biological ageing. These observations require further study to tease out potential mechanistic links.
Databáze: OpenAIRE
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