Decreased half-life time of plasma von Willebrand factor collagen binding activity in essential thrombocythaemia: normalization after cytoreduction of the increased platelet count
| Autor: | Irene S. Lucas, Fransisco J Prins, Roel van Strik, Desiree Van De Moesdijk, Jan Jacques Michiels, Perry J. J. Van Genderen, Huub H.D.M. van Vliet |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Von Willebrand factor In vivo hemic and lymphatic diseases Internal medicine von Willebrand Factor medicine Humans Platelet Von Willebrand factor.collagen binding activity Desmopressin Aged biology Platelet Count business.industry Increased platelet count Half-life Hematology Middle Aged Endocrinology Tissue Plasminogen Activator biology.protein Female Collagen business Homeostasis Half-Life Thrombocythemia Essential circulatory and respiratory physiology medicine.drug |
| Zdroj: | British Journal of Haematology. 99:832-836 |
| ISSN: | 0007-1048 |
| Popis: | Patients with essential thrombocythaemia (ET) exhibit a decrease of large von Willebrand factor (VWF) multimers in plasma, which is inversely related to the platelet count. In the present study we investigated whether the decrease of large VWF multimers in plasma with increasing platelet counts is the consequence of increased turnover of large VWF multimers in vivo. To that end we measured the half-life times of endogenously released VWF:Ag and VWF:CBA (collagen binding activity) after intravenous administration of desmopressin (DDAVP) to nine ET patients and nine control subjects (N). In addition, the half-life times of VWF:Ag and VWF:CBA were also measured in four ET patients after cytoreduction of the increased platelet count to normal or nearly normal values. Estimated half-life times of VWF:Ag did not differ between ET patients and normals (11.0 ± 4.0 h v 12.4 ± 2.5 h, P > 0.05). Estimated half-life times of VWF:CBA were significantly lower in ET patients as compared with normal individuals (6.1 ± 2.0 h v 8.4 ± 2.5 h, P |
| Databáze: | OpenAIRE |
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