Analysis of IL-12 Receptor β2 Chain Expression of Circulating T Lymphocytes in Patients with Atopic Asthma
| Autor: | Tsuyoshi Sakane, Adachi Mitsuru, Kenji Minoguchi, Noboru Suzuki, Takuya Yokoe |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent T-Lymphocytes Receptor expression Immunology Gene Expression Enzyme-Linked Immunosorbent Assay Biology Antibodies Interleukin 21 Th2 Cells Antibody Specificity Internal medicine Interleukin-4 receptor medicine Humans RNA Messenger IL-2 receptor Cells Cultured Common gamma chain ZAP70 Interleukin-18 Receptors Interleukin-12 Dust Receptors Interleukin Th1 Cells Interleukin-12 Asthma Interleukin 10 Endocrinology Interleukin-21 receptor Female Interleukin-4 |
| Zdroj: | Cellular Immunology. 208:34-42 |
| ISSN: | 0008-8749 |
| DOI: | 10.1006/cimm.2001.1759 |
| Popis: | Th2 cell predominance relative to Th1 cells contributes to pathological immune responses in patients with atopic asthma. IL-12 is a key cytokine in the induction of Th1 cells, and downregulation of IL-12 production is reported in these patients. However, IL-12 receptor expression of their T lymphocytes has not been clarified. In this study, expression of IL-12 receptor beta 2 on T cells and secretion of cytokines which affect IL-12 receptor beta 2 expression by their PBMC were examined. We found that IL-12 receptor beta 2 expression of the T cells is reduced. This is partly due to the diminished production of IL-12 and enhanced secretion of IL-4 by their PBMC. IL-18 production is not significantly modulated in these patients. Furthermore, intrinsic defects of the CD4(+) T cells, which reduce their IL-12 receptor beta 2 expression in response to IL-12 and/or IL-18 stimulation, are evident and are importantly involved in the Th1/Th2 imbalance of patients with atopic asthma. |
| Databáze: | OpenAIRE |
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