Role of the Kv4.3 K+ channel in ventricular muscle. A molecular correlate for the transient outward current
| Autor: | Hong-Sheng Wang, David McKinnon, Ira S. Cohen, Hangang Yu, Christine McDonald, Jane E. Dixon, Wenmei Shi, Randy S. Wymore |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Potassium Channels Physiology Heart Ventricles Molecular Sequence Data Biology Ventricular action potential Dogs Internal medicine medicine Myocyte Animals Humans Amino Acid Sequence Cloning Molecular Cells Cultured Cardiac transient outward potassium current Ion Transport Voltage-gated ion channel Cardiac muscle Potassium channel Cell biology Rats Electrophysiology medicine.anatomical_structure Endocrinology Shal Potassium Channels Ventricle Potassium Channels Voltage-Gated cardiovascular system Cardiology and Cardiovascular Medicine Sequence Alignment Sequence Analysis |
| Zdroj: | Circulation research. 79(4) |
| ISSN: | 0009-7330 |
| Popis: | The expression of 15 different K + channels in canine heart was examined, and a new K + channel gene (Kv4.3), which encodes a rapidly inactivating K + current, is described. The Kv4.3 channel was found to have biophysical and pharmacological properties similar to the native canine transient outward current (I to ). The Kv4.3 gene is also expressed in human and rat heart. It is concluded that the Kv4.3 channel underlies the bulk of the I to in canine ventricular myocytes, and probably in human myocytes. Both the Kv4.3 and Kv4.2 channels are likely to contribute to the I to in rat heart, and differential expression of these two channels can account for observed differences in the kinetic properties of the I to in different regions of rat ventricle. There are significant differences in the pattern of K + channel expression in canine heart, compared with rat heart, and these differences may be an adaptation to the different requirements for cardiac function in mammals of markedly different sizes. It is possible that the much longer ventricular action potential duration observed in canine heart compared with rat heart is due, in part, to the lower levels of Kv1.2, Kv2.1, and Kv4.2 gene expression in canine heart. |
| Databáze: | OpenAIRE |
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