An animal model for the study of chronic hypoxemia including long-term follow-up results

Autor:	S. Bert Litwin, Kenneth A. Wright, Myron B. Laver, Amnon Rosenthal, James E. Youker, William F. Skogen
Rok vydání:	1978
Předmět:	medicine.medical_specialty Long term follow up Left atrium Aorta Thoracic Vena Cava Inferior Inferior vena cava Hypoxemia Hemoglobins Animal model Dogs Chronic hypoxemia Internal medicine medicine Pulmonary blood flow Animals Humans Transplantation Homologous cardiovascular diseases Heart Atria Hypoxia business.industry Hemodynamics respiratory tract diseases Shunt (medical) Disease Models Animal medicine.anatomical_structure Carotid Arteries medicine.vein Hematocrit cardiovascular system Cardiology Surgery medicine.symptom Blood Gas Analysis business circulatory and respiratory physiology Follow-Up Studies
Zdroj:	The Journal of surgical research. 24(2)
ISSN:	0022-4804
Popis:	We have used a modified technique to create long-standing hypoxemia in dogs. An aortic homograft was inserted between the inferior vena cava and left atrium, after which the caval-right junction was ligated. The resulting obligatory right-to-left shunt and diminished pulmonary blood flow caused significant and predictable hypoxemia and polycythemia. This animal model may be useful in the study of effects of chronic shunt hypoxemia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbfac47de04d0cdc31e7dbdbf2b64216 https://pubmed.ncbi.nlm.nih.gov/625102 Zobrazit plný text záznamu