Elevated plasma level of the glycolysis byproduct methylglyoxal on admission is an independent biomarker of mortality in ICU COVID-19 patients

Autor: Fadhel A. Alomar, Marai N. Alshakhs, Salah Abohelaika, Hassan M. Almarzouk, Mohammed Almualim, Amein K. Al-Ali, Fahad Al-Muhanna, Mohammed F. Alomar, Mousa J. Alhaddad, Mohammed S. Almulaify, Faisal S. Alessa, Ahmed S. Alsalman, Ahmed Alaswad, Sean R. Bidasee, Hassan Alsaad, Rudaynah A Alali, Mona H. AlSheikh, Mohammed S. Akhtar, Mohammed Al Mohaini, Abdulkhaliq J. Alsalman, Hussain Alturaifi, Keshore R. Bidasee
Rok vydání: 2021
Předmět:
Zdroj: Scientific reports. 12(1)
ISSN: 2045-2322
Popis: Biomarkers to identify ICU COVID-19 patients at high risk for mortality are urgently needed for therapeutic care and management. Here we found plasma levels of the glycolysis byproduct methylglyoxal (MG) were 4.4-fold higher in ICU patients upon admission that later died (n = 33), and 1.7-fold higher in ICU patients that survived (n = 32),compared to uninfected controls (n = 30). The increased MG in patients that died correlated inversely with the levels of the MG-degrading enzyme glyoxalase-1 (r2 = − 0.50), and its co-factor glutathione (r2 = − 0.63), and positively with monocytes (r2 = 0.29). The inflammation markers, SSAO (r2 = 0.52), TNF-α (r2 = 0.41), IL-1β (r2 = 0.25), CRP (r2 = 0.26) also correlated positively with MG. Logistic regression analysis provides evidence of a significant relationship between the elevated MG upon admission into ICU and death (P
Databáze: OpenAIRE
Externí odkaz: