Translational recoding: canonical translation mechanisms reinterpreted

Autor:	Tamara Senyushkina, Mariia Klimova, Ingo Wohlgemuth, Bee-Zen Peng, Marina V. Rodnina, Natalia Korniy, Frank Peske, Cristina Maracci, Riccardo Belardinelli, Prajwal Karki, Ekaterina Samatova
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Messenger RNA Frameshifting Ribosomal Computational biology Biology Ribosome Stop codon Eukaryotic translation Terminator (genetics) Protein sequencing Protein Biosynthesis Transfer RNA Genetics Protein biosynthesis Codon Terminator Survey and Summary Ribosomes
Zdroj:	Nucleic Acids Research
ISSN:	1362-4962 0305-1048
Popis:	During canonical translation, the ribosome moves along an mRNA from the start to the stop codon in exact steps of one codon at a time. The collinearity of the mRNA and the protein sequence is essential for the quality of the cellular proteome. Spontaneous errors in decoding or translocation are rare and result in a deficient protein. However, dedicated recoding signals in the mRNA can reprogram the ribosome to read the message in alternative ways. This review summarizes the recent advances in understanding the mechanisms of three types of recoding events: stop-codon readthrough, –1 ribosome frameshifting and translational bypassing. Recoding events provide insights into alternative modes of ribosome dynamics that are potentially applicable to other non-canonical modes of prokaryotic and eukaryotic translation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf57e9683df2261a163fa7e199a1668 http://europepmc.org/articles/PMC7026636 Zobrazit plný text záznamu