Vitamin A Deficiency and the Lung
| Autor: | Teresa Barber, María Pilar Marín, Cabezuelo Mt, Rodríguez-Fernández L, Luis Enrique Nores Torres, Rosa Zaragozá, Viña, Joaquín Timoneda |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Vitamin collagen Lung Diseases Epithelial-Mesenchymal Transition extracellular matrix Retinoic acid lcsh:TX341-641 Review epithelial–mesenchymal transition lung Extracellular matrix 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Risk Factors retinoic acid Medicine Animals Humans 030212 general & internal medicine Vitamin A N-cadherin pulmonary disease Nutrition and Dietetics Lung business.industry Vitamin A Deficiency Regeneration (biology) Retinol E-cadherin Micronutrient medicine.disease Vitamin A deficiency 030104 developmental biology medicine.anatomical_structure E-cadherin N-cadherin Vitamin A deficiency collagen epithelial–mesenchymal transition extracellular matrix lung pulmonary disease retinoic acid retinol chemistry Immunology Airway Remodeling business lcsh:Nutrition. Foods and food supply Food Science retinol Signal Transduction |
| Zdroj: | Nutrients r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname r-FISABIO. Repositorio Institucional de Producción Científica r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) Nutrients, Vol 10, Iss 9, p 1132 (2018) |
| ISSN: | 2072-6643 |
| Popis: | Vitamin A (all-trans-retinol) is a fat-soluble micronutrient which together with its natural derivatives and synthetic analogues constitutes the group of retinoids. They are involved in a wide range of physiological processes such as embryonic development, vision, immunity and cellular differentiation and proliferation. Retinoic acid (RA) is the main active form of vitamin A and multiple genes respond to RA signalling through transcriptional and non-transcriptional mechanisms. Vitamin A deficiency (VAD) is a remarkable public health problem. An adequate vitamin A intake is required in early lung development, alveolar formation, tissue maintenance and regeneration. In fact, chronic VAD has been associated with histopathological changes in the pulmonary epithelial lining that disrupt the normal lung physiology predisposing to severe tissue dysfunction and respiratory diseases. In addition, there are important alterations of the structure and composition of extracellular matrix with thickening of the alveolar basement membrane and ectopic deposition of collagen I. In this review, we show our recent findings on the modification of cell-junction proteins in VAD lungs, summarize up-to-date information related to the effects of chronic VAD in the impairment of lung physiology and pulmonary disease which represent a major global health problem and provide an overview of possible pathways involved. |
| Databáze: | OpenAIRE |
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