Free fatty acid concentration in maternal plasma and fetal body fat content
| Autor: | Fredric Solomon, Peter S. Mueller, James R. Brown |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Pregnancy in Diabetics Blood sugar Blood lipids Fatty Acids Nonesterified Subcutaneous injection Fetus Pregnancy Internal medicine Diabetes mellitus Diabetes Mellitus medicine Animals Obesity Pharmacology chemistry.chemical_classification Heparin business.industry Research Fatty Acids Obstetrics and Gynecology Fatty acid medicine.disease Lipids Rats Endocrinology Adipose Tissue chemistry Pregnancy Animal Gestation Female business |
| Zdroj: | American Journal of Obstetrics and Gynecology. 88:196-203 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/0002-9378(64)90255-8 |
| Popis: | Subcutaneous injection of 200 U.S.P. units of heparin into female Sprague-Dawley rats produced large and sustained elevations of plasma free fatty acids but no significant change in blood glucose. A group of pregnant rats received such injections of heparin 3 times daily throughout pregnancy. The fetuses from mothers of this group, at 19½ and 21½ days of gestation, had significantly more body fat than the fetuses from uninjected mothers. The hypothesis is presented that the maternal free fatty acid concentration in part determines fetal fat accumulation. It is proposed that the body composition changes noted in babies of mothers with diabetes might thus be ascribed to abnormally high maternal plasma free fatty acid concentrations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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