Absence of HTLV-1 related sequences in MS from high prevalence areas in western Norway
| Autor: | Harald Nyland, K. H. Kalland, D. E. Helland, P. Frost, Rune Midgard, K. M. Myhr, M. Grønning |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Multiple Sclerosis viruses Prevalence Biology Polymerase Chain Reaction Virus law.invention Retrovirus law Risk Factors medicine Humans Gene Polymerase chain reaction Norway Multiple sclerosis Incidence (epidemiology) Incidence General Medicine Provirus Middle Aged biology.organism_classification medicine.disease Virology HTLV-I Infections Blotting Southern Cross-Sectional Studies Neurology Immunology Female Neurology (clinical) |
| Zdroj: | Acta neurologica Scandinavica. 89(1) |
| ISSN: | 0001-6314 |
| Popis: | In Western Norway, long-term follow up epidemiological studies have revealed significant increases in the incidence and prevalence rates of multiple sclerosis (MS) in stable populations, indicating the impact of exogenous factors. In this study 183 MS patients and 102 controls from high prevalence areas in Western Norway were investigated for human T-lymphotropic virus type I (HTLV-1) related sequences by polymerase chain reaction. Using primers targeting the gag, pol and env genes in the HTLV-1 provirus genome, no amplification products were detected in the 183 MS patients or 102 controls. The results strongly suggest that neither HTLV-1 nor a closely related retrovirus participate in the aetiology of MS. |
| Databáze: | OpenAIRE |
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