A Case Series of Granulomatosis With Polyangiitis Primarily Diagnosed by Otological Manifestations
| Autor: | Ronald Sahyouni, Phuonganh Le, Jack Birkenbeuel, Dillon Cheung, Omid Moshtaghi, Hamid R. Djalilian, Mehdi Abouzari, Harrison W. Lin |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Hearing loss Clinical Sciences ANCA-Associated Vasculitis Diagnosis Differential otology 03 medical and health sciences Young Adult 0302 clinical medicine Audiometry Otology Clinical Research Diagnosis medicine Humans 2.1 Biological and endogenous factors Aetiology 030223 otorhinolaryngology Hearing Loss Retrospective Studies Aged ANCA associated vasculitis 030203 arthritis & rheumatology granulomatosis with polyangiitis business.industry Otitis Media with Effusion Eustachian Tube Granulomatosis with Polyangiitis Wegener’s granulomatosis General Medicine Middle Aged medicine.disease Dermatology Wegener's granulomatosis Otitis Media Infectious Diseases Otorhinolaryngology Differential Female medicine.symptom Granulomatosis with polyangiitis business |
| Zdroj: | The Annals of otology, rhinology, and laryngology, vol 128, iss 3 Sahyouni, Ronald; Moshtaghi, Omid; Abouzari, Mehdi; Le, Phuonganh; Birkenbeuel, Jack; Cheung, Dillon; et al.(2018). A Case Series of Granulomatosis With Polyangiitis Primarily Diagnosed by Otological Manifestations.. The Annals of otology, rhinology, and laryngology, 3489418815517. doi: 10.1177/0003489418815517. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/4557x20h |
| Popis: | Objective: To describe a case series of previously undiagnosed granulomatosis with polyangiitis (GPA) patients who presented primarily with otological manifestations. Method: We report a series of patients visited at a neurotology clinic who were eventually diagnosed with GPA based on their otologic complaints and had no prior knowledge of having this condition. Results: In this series, 10 (91%) patients presented with hearing loss (HL), more than half of which were bilateral (60%). Upon audiometric examination, all but 1 patient had mixed, conductive, or sensorineural HL. All patients presented with eustachian tube dysfunction (ETD), otitis media with effusion (OME), or both. Nasal endoscopy showed intranasal pathology in 3 (27%) patients. Otologic symptoms were improved in all patients after treatment with an average of 4 in-office follow-up appointments. Conclusion: GPA should be included in the differential diagnosis of adults with unexplained mixed hearing loss, new onset serous effusion, or acute otitis media in the absence of a previous history of ETD. Laboratory tests (ie, anti-neutrophil cytoplasmic autoantibody, erythrocyte sedimentation rate, and C-reactive protein) along with a urinalysis can aid in screening these patients. In cases in which the index of suspicion is high, repeated testing could reduce the risk of false negative findings. |
| Databáze: | OpenAIRE |
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