Non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma
| Autor: | Javier Crespo, Fernando Pons-Romero, Agustín Domínguez, Aitor Orive, José Carlos Fernández-Escalante, Covadonga García-Suarez, Antonio Cuadrado |
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| Předmět: |
medicine.medical_specialty
Cirrhosis Carcinoma Hepatocellular Endocrinology Diabetes and Metabolism Disease digestive system Gastroenterology Hepatitis Insulin resistance Diabetes mellitus Internal medicine medicine Humans Obesity Aged Nutrition and Dietetics business.industry Fatty liver Liver Neoplasms nutritional and metabolic diseases Middle Aged medicine.disease digestive system diseases Fatty Liver Diabetes Mellitus Type 2 Hepatocellular carcinoma Disease Progression Surgery Female Steatosis Steatohepatitis business Follow-Up Studies |
| Zdroj: | Scopus-Elsevier |
| Popis: | Non-alcoholic fatty liver disease (NAFLD) is characterized by an excessive accumulation of fatty acids and triglycerides within the cytoplasm of the hepatocytes of non-alcohol users. The natural history varies according to the initial histological diagnosis. A current consideration is that cryptogenic cirrhosis may be representative of a late stage of non-alcoholic steatohepatitis (NASH), which has lost its features of necroinflammatory activity and steatosis in up to 80% of patients. Since NASH is able to progress to cirrhosis, hepatocellular carcinoma (HCC) development may be an end-stage of this disease. We report below two clinical cases of patients diagnosed with NASH who developed HCC. The relationship between NAFLD and HCC is reviewed. |
| Databáze: | OpenAIRE |
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