Living with female rats exposed to restraint stress during pregnancy caused depressive‐like behavior in male rats and stress‐induced apoptosis
| Autor: | Leman Sencar, Eylem Taskin, Kubra Akillioglu, Ozge Cevik, Ayper Boga, Celal Güven, Leyla Sahin, Sayad Kocahan, Sait Polat |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Restraint Physical Postpartum depression Elevated plus maze medicine.medical_specialty Apoptosis Anxiety Hippocampus Developmental Neuroscience Pregnancy Internal medicine Animals Medicine Hippocampus (mythology) Rats Wistar TUNEL assay Behavior Animal Depression business.industry medicine.disease Housing Animal Rats Mood Endocrinology Female business Stress Psychological Postpartum period Developmental Biology Behavioural despair test |
| Zdroj: | International Journal of Developmental Neuroscience. 81:643-654 |
| ISSN: | 1873-474X 0736-5748 |
| Popis: | OBJECTIVE Maternal mood disorders such as postpartum depression (PPD) can negatively affect the lives not only of mothers but also of partners. The purpose of this study investigates emotional behavior and hippocampal apoptosis alterations of the male live with a postpartum depressed female. METHODS Pregnant rats in the stress group were exposed to restraint stress (RS). The male rats who shared the same cages were not exposed to RS. To explain the consequences of depressive-like behavior and anxiety, animals were exposed to the forced swim test (FST), open-field test (OFT), and elevated plus maze (EPM). The apoptotic cell number was detected by terminal deoxynucleotidyl transferase (Tdt)-mediated dUTP biotin nick-end labeling (TUNEL) staining. RESULTS According to FST, PPD caused more immobility, reduced swimming, and climbing compared to control groups in the stressed female and male (p |
| Databáze: | OpenAIRE |
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