The serum levels of testosterone in coronary artery disease patients; relation to NO, eNOS, endothelin-1, and disease severity
| Autor: | Masoud Pezeshkian, Mohammad Nouri, Mohammad-Ali Karimi, Saeideh Akseh, Ahmadreza Jodati, Yousef Faridvand, Amir Valizadeh, Nasser Safaie, Dara Rahmanpour |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Nitric Oxide Synthase Type III Endocrinology Diabetes and Metabolism Coronary Artery Disease Endothelial NOS Nitric Oxide Gastroenterology Severity of Illness Index Nitric oxide Pathogenesis Coronary artery disease chemistry.chemical_compound Endocrinology Enos Internal medicine medicine Humans Testosterone Endothelial dysfunction Molecular Biology biology Endothelin-1 business.industry Testosterone (patch) General Medicine medicine.disease biology.organism_classification Endothelin 1 chemistry business |
| Zdroj: | Hormone molecular biology and clinical investigationReferences. 43(1) |
| ISSN: | 1868-1891 |
| Popis: | Objectives The changes in testosterone level and its correlation with the endothelial nitric oxide systems balance in patients with coronary artery disease (CAD) remains uncertain. Therefore, in our study, we aimed to evaluate the levels of testosterone, endothelin-1 (ET-1), nitric oxide (NO), and endothelial NOS (eNOS) in CAD patients, and control group to find the relationship between these parameters and disease severity. Methods Forty-four patients as CAD group with significant (≥50%) stenosis confirmed by angiography was included in the study, and 40 healthy men were included as the control group. According to the number of vessels obstruction, CAD severity was determined. The serum indicated parameters were assessed to discriminate between patients and controls. Results It was found that testosterone levels in the CDA group were significantly lower than those of the control group (p Conclusions The current study reports that serum levels of testosterone are closely related to endothelial NO levels and might be of relevance to the pathogenesis of endothelial dysfunction and disease severity in CAD patients. |
| Databáze: | OpenAIRE |
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