Developmental toxicity assessment of thermoresponsive poly(N-isopropylacrylamide-co-acrylamide) oligomers in CD-1 mice
| Autor: | Induvadana Ankareddi, Christopher S. Brazel, Jane F. Rasco, Ronald D. Hood, Melissa M. Bailey |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Embryology medicine.medical_specialty Dose Polymers Health Toxicology and Mutagenesis Acrylic Resins Developmental toxicity Embryonic Development Mice Inbred Strains Toxicology Mice chemistry.chemical_compound Pregnancy In vivo Internal medicine medicine Animals Conceptus Drug Carriers Fetus Dose-Response Relationship Drug Temperature Abnormalities Drug-Induced Fetal Resorption Endocrinology Fetal Weight chemistry Maternal Exposure Acrylamide Drug delivery Female medicine.symptom Weight gain Developmental Biology |
| Zdroj: | Birth Defects Research Part B: Developmental and Reproductive Toxicology. 83:112-116 |
| ISSN: | 1542-9741 1542-9733 |
| DOI: | 10.1002/bdrb.20150 |
| Popis: | BACKGROUND: Although polymers and hydrogels are used successfully in biomedical applications, including implants and drug delivery devices, smaller molecular weight oligomers, such as those investigated here, have not been extensively studied in vivo. Poly(N-isopropylacrylamide-co-acrylamide), or P(NIPAAm-co-AAm), has a unique thermoresponsive behavior and is under investigation as a novel drug delivery system for metastatic cancer treatment. To date, no studies have been published regarding the safety of P(NIPAAm-co-AAm) to the conceptus. METHODS: From gestation days (GD) 6–16, pregnant CD-1 mice were dosed via i.p. injection with aqueous solutions containing 500, 750, or 1,000 mg/kg/d P(NIPAAm-co-AAm). Dams were sacrificed on GD 17 and their litters were examined for abnormalities. RESULTS: P(NIPAAm-co-AAm) caused no statistically significant difference in maternal weight gain or percent resorbed or dead fetuses compared to control values, but fetal weight was significantly decreased in the two highest dosage groups. CONCLUSIONS: At the highest dosages employed, maternal exposure to P(NIPAAm-co-AAm) was associated with decreased fetal weight. However, as the estimated human exposure levels for persons using this system would be some 1,500-fold lower than the lowest dosage administered in this study, the authors feel that this oligomer was not shown to pose a biologically significant risk at relevant human dosages. Birth Defects Res (Part B), 2008. © 2008 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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