| Autor: |
Jaclyn M Goodrich, Alesia M Jung, Melissa A Furlong, Shawn Beitel, Sally Littau, John Gulotta, Darin Wallentine, Jefferey L Burgess |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Occupational and environmental medicine. 79(10) |
| ISSN: |
1470-7926 |
| Popis: |
ObjectivesFirefighters face exposures associated with adverse health outcomes including risk for multiple cancers. DNA methylation, one type of epigenetic regulation, provides a potential mechanism linking occupational hazards to adverse health outcomes. We hypothesised that DNA methylation profiles would change in firefighters after starting their service and that these patterns would be associated with occupational exposures (cumulative fire-hours and fire-runs).MethodsWe profiled DNA methylation with the Infinium MethylationEPIC in blood leucocytes at two time points in non-smoking new recruits: prior to live fire training and 20–37 months later. Linear mixed effects models adjusted for potential confounders were used to identify differentially methylated CpG sites over time using data from 50 individuals passing all quality control.ResultsWe report 680 CpG sites with altered methylation (q value ConclusionsOverall, this study provides evidence that DNA methylation may be altered by fireground exposures, and the impact of this change on disease development should be evaluated. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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