Plant cell culture extract of Cirsium eriophorum with skin pore refiner activity by modulating sebum production and inflammatory response
| Autor: | Sonia Laneri, Ritamaria Di Lorenzo, Claudia Zappelli, Assunta Tortora, Marida Bimonte, Antonia Sacchi, Maria Gabriella Colucci, Maura Angelillo, Annalisa Tito, Irene Dini, Antonietta Bernardi, Fabio Apone |
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| Přispěvatelé: | Laneri, Sonia, Dini, Irene, Tito, Annalisa, Di Lorenzo, Ritamaria, Bimonte, Marida, Tortora, Assunta, Zappelli, Claudia, Angelillo, Maura, Bernardi, Antonietta, Sacchi, Antonia, Gabriella Colucci, Maria, Apone, Fabio |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Cirsium eriophorum Sebum production Anti-Inflammatory Agents Cell Culture Techniques Cosmetics Exfoliation (cosmetology) Cirsium Desquamation Young Adult 03 medical and health sciences 0302 clinical medicine Skin Physiological Phenomena Plant cell culture Acne Vulgaris medicine Stratum corneum HaCaT Cells Humans Skin Inflammation Pharmacology 0303 health sciences acne-prone C. eriophorum cell cultures dermo-cosmetic mattifying effect oily skin sebumnormalizing integumentary system biology Plant Extracts Chemistry 030302 biochemistry & molecular biology Kallikrein Fibroblasts biology.organism_classification Cell biology Sebum medicine.anatomical_structure Cell culture Face 030220 oncology & carcinogenesis Female medicine.symptom |
| Zdroj: | Phytotherapy Research. 35:530-540 |
| ISSN: | 1099-1573 0951-418X |
| DOI: | 10.1002/ptr.6832 |
| Popis: | Facial pore enlargement is considered a significant esthetic and health concern in skincare cosmetics. The pores fulfill the critical function of keeping the skin surface hydrated and protected against microbial infections. The hyperseborrhea, the stress factors, and the hormonal triggers can cause pore size enlargement, causing higher susceptibility of the skin to microbe aggressions and inflammatory reactions. Thus, reducing excessive sebum production and keeping functional pores are two of the most requested activities in skincare cosmetics. A Cirsium eriophorum cell culture extract was investigated for its role in sebum regulation, stratum corneum desquamation, and anti-inflammation. The extract was able to regulate essential markers associated with sebum secretion and pore enlargements, such as the enzyme 5α-reductase, which plays a central role in sebum production, and the trypsin-like serine protease Kallikrein 5, which promotes skin exfoliation and antimicrobial response. Moreover, the extract showed a sebum-normalizing and pore refining activity in individuals having seborrheic or acne-prone skins, suggesting a role of the C. eriophorum extract in rebalancing altered skin conditions responsible for pore enlargement. |
| Databáze: | OpenAIRE |
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