Effects of an Exercise Intervention on Immunologic Parameters in Frail Elderly Nursing Home Residents
| Autor: | Michael Kutner, John L. Fahey, John F. Schnelle, Zoher F. Kapasi, Joseph G. Ouslander |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Aging
medicine.medical_specialty Frail Elderly T-Lymphocytes Receptors Tumor Necrosis Factor law.invention chemistry.chemical_compound Immune system CD28 Antigens Randomized controlled trial Antigens CD Heart Rate law Intervention (counseling) Heart rate Humans Receptors Tumor Necrosis Factor Type II Medicine Lymphocyte Count Aged Aged 80 and over Physical Education and Training business.industry Incidence (epidemiology) Neopterin Receptors Interleukin-2 HLA-DR Antigens Lymphocyte Subsets Exercise Therapy Nursing Homes Killer Cells Natural Clinical trial Solubility chemistry Immune System Humoral immunity Physical Endurance Physical therapy Geriatrics and Gerontology business Immunologic Memory Cell Division |
| Zdroj: | The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 58:M636-M643 |
| ISSN: | 1758-535X 1079-5006 |
| Popis: | Background. Aging is associated with decline in both cell-mediated and humoral immunity and may contribute to increased incidence and severity of infections in frail elderly. Exercise, depending on intensity, has significant effects on the immune system. We conducted a randomized, controlled clinical trial of a 32-week functionally oriented exercise program in frail elderly living in nursing homes and determined whether the exercise intervention was associated with a change in immune parameters in this frail elderly nursing home population. Methods. Nursing home residents were randomly assigned to an intervention (n ¼94) and control group (n ¼96). The intervention consisted of a functionally oriented endurance and resistance exercise training that was provided every 2 hours from 8:00 AM to 4:00 PM for 5 days a week for 8 months. Lymphocyte subpopulations, including activation markers (CD28, CD25, HLA-DR), in vitro proliferation, and soluble products of cytokine activity (neopterin and sTNF-RII) in serum were measured by taking blood samples at baseline and after 8 weeks and 32 weeks of the intervention. Results. Exercise training did not induce changes in lymphocyte subpopulations, activation markers (CD28, CD25, HLA-DR), in vitro proliferation, and soluble products of cytokine activity (neopterin and sTNF-RII) in serum. Conclusions. A 32-week exercise intervention did not bring about beneficial or detrimental effects on immune parameters in the frail elderly nursing home population and may explain why the intervention was not associated with a change in the incidence of infections in the intervention group compared with the control group. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|