Low Sodium Modifies the Vascular Effects of Angiotensin-Converting Enzyme Inhibitor Therapy in Healthy Rats
| Autor: | Hendrik Buikema, Simone Gschwend, Dick de Zeeuw, Menno J. A. Kocks, Gerjan Navis |
|---|---|
| Přispěvatelé: | Faculteit Medische Wetenschappen/UMCG, Kidney Health Institute - Khis, Lifestyle Medicine, Vasculal Ageing Programme |
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
DILATION EXPERIMENTAL HEART-FAILURE Adrenergic Angiotensin-Converting Enzyme Inhibitors Vasodilation RESISTANCE ARTERIES Contractility Food-Drug Interactions MESENTERIC ARTERIAL BED Lisinopril Internal medicine medicine Animals Rats Wistar Endothelial dysfunction SPONTANEOUSLY HYPERTENSIVE RATS Mesenteric arteries ACE-INHIBITION Pharmacology business.industry Sodium CYCLOOXYGENASES Sodium Dietary EFFICACY medicine.disease Acetylcholine Rats medicine.anatomical_structure Blood pressure Endocrinology ENDOTHELIAL DYSFUNCTION Prostaglandins Blood Vessels Molecular Medicine business Low sodium medicine.drug |
| Zdroj: | Journal of Pharmacology and Experimental Therapeutics, 310(3), 1183-1189. WILLIAMS & WILKINS |
| ISSN: | 1521-0103 0022-3565 |
| Popis: | Low dietary sodium (LS) increases the effect of angiotensin-converting enzyme (ACE) inhibitor therapy in patients and experimental models, but mechanisms underlying this enhanced efficacy are largely unknown. Because the benefits of ACE inhibition are mediated to a considerable extent by their effect on the vasculature, we studied whether low sodium alters the vascular effects of ACE inhibition. Baseline functional and morphological characteristics, and endothelium-dependent and -independent dilatory responses were studied in isolated perfused small intrarenal and mesenteric arteries obtained from control rats (CON), rats on LS, lisinopril-treated rats (CON-LIS), or rats treated with lisinopril during LS (LS-LIS). We found, first, that LS-LIS compared with CON-LIS enhances blood pressure reduction. Second, interlobar renal arteries had increased lumen diameter and reduced adrenergic contractility in CON-LIS compared with CON, without additional effects of LS. In contrast, mesenteric arteries were not altered in CON-LIS compared with CON, but became triggered for increased myogenic and adrenergic constriction in LS-LIS. Third, LS-LIS decreased acetylcholine (ACh)-induced vasodilation in both mesenteric and renal arteries compared with CON-LIS. During the latter condition, opposite prostaglandins are involved in the endothelial function of the two different vascular beds, i.e., increased involvement of contractile prostaglandins in ACh-induced vasodilatation in renal arteries, versus dilatory prostaglandins in mesenteric arteries. Whether cause or consequence of the enhanced blood pressure response, our data demonstrate a modifying effect of dietary sodium on vascular effects of ACE inhibition. These findings provide a rationale for further studies addressing the mechanism-of-actions of our therapies to find additional strategies to improve therapy response. |
| Databáze: | OpenAIRE |
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