Antihypertensive Effect of 0.1-Hz Blood Pressure Oscillations to the Kidney
| Autor: | Erdmann Seeliger, Benno Nafz, Jens Stegemann, H. Wolfgang Reinhardt, Ingolf Schimke, Pontus B. Persson, Nadja Richter, Morton H. Bestle |
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| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Hypertension Renal Renal function Hemodynamics Blood Pressure Kidney Nitric Oxide Plasma renin activity Renal Circulation Excretion Dogs Physiology (medical) Internal medicine Renin Renin–angiotensin system medicine Animals Fourier Analysis business.industry Blood pressure Endocrinology medicine.anatomical_structure Renal blood flow Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Capital Region of Denmark |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.101.5.553 |
| Popis: | Background —Physiological blood pressure (BP) fluctuations with frequencies >0.1 Hz can override renal blood flow autoregulation. The influence of such immediate changes in renal perfusion pressure (RPP) on daily BP regulation, eg, via shear stress–stimulated liberation of renal endothelial NO, however, is unknown. Thus, we studied the effects of such RPP oscillations on renal function and on systemic BP during the onset of renal hypertension. Methods and Results —Seven beagles (randomly assigned to each of the following protocols) were chronically instrumented for the measurement of systemic BP, RPP, and renal excretory function. An inflatable cuff was used to reduce and to oscillate RPP over 24 hours in the freely moving dog. Reducing RPP to 87±2 mm Hg diminished excretion of sodium and water and doubled plasma renin activity (PRA, n=7, P Conclusions —BP fluctuations transiently stimulate NO liberation and induce a reduction in PRA, which enhances 24-hour sodium and water excretion and markedly attenuates the acute development of renovascular hypertension. |
| Databáze: | OpenAIRE |
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