Gut microbiota signatures and clinical manifestations in celiac disease children at onset: a pilot study
| Autor: | Luigi Colecchia, Lorenzo Iughetti, Federico Ravaioli, Elton Dajti, Antonio Colecchia, Anna Rita Di Biase, Virginia D'Amico, Giovanni Marasco, Beatrice Righi, Davide Festi |
|---|---|
| Přispěvatelé: | Di Biase A.R., Marasco G., Ravaioli F., Dajti E., Colecchia L., Righi B., D'Amico V., Festi D., Iughetti L., Colecchia A. |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Abdominal pain Duodenum diarrhea Pilot Projects Disease Gut flora medicine.disease_cause Gastroenterology Feces 03 medical and health sciences stool microbiota 0302 clinical medicine Enterobacteriaceae Internal medicine duodenal microbiota medicine Humans Age of Onset Child Bacillaceae Akkermansia Hepatology biology Bacteroidetes Streptococcus business.industry Fusobacterium medicine.disease biology.organism_classification Gastrointestinal Microbiome Celiac Disease Diarrhea 030220 oncology & carcinogenesis Dysbiosis Female 030211 gastroenterology & hepatology medicine.symptom business |
| Zdroj: | Journal of Gastroenterology and Hepatology. 36:446-454 |
| ISSN: | 1440-1746 0815-9319 |
| DOI: | 10.1111/jgh.15183 |
| Popis: | Background and Aim: Recent researches have shown an altered gut microbiota in celiac disease (CD) patients compared with healthy controls (HCs). This study aims to evaluate the composition of the microbiota of CD children at onset and the relationship between bacterial abundances and symptoms. Methods: Celiac disease patients were consecutively enrolled at a pediatric unit referring for suspected CD. HCs were also included in the study. Stool and duodenal samples were collected and evaluated by a high taxonomic fingerprint microbiota array. Results: Thirty-seven subjects enrolled: 21 CD patients and 16 HCs. Fourteen subjects were male (38%). The mean age was 75months (standard deviation 31.5) for CD patients and 71months (standard deviation 34.9) for HCs. Duodenal microbiota of CD patients showed a dominance of Enterobacteriaceae and subdominance of Bacteroidetes/Streptococcus. Stool microbiota showed a lower abundance of Bacteroides–Prevotella (P=0.013), Akkermansia (P=0.002), and Staphylococcaceae (P=0.001) in CD patients compared with HC. At symptoms level, an increased mean relative abundance of Bacillaceae and Enterobaeriaceae in patients with abdominal pain (P=0.007 and P=0.010) was found. CD patients with diarrhea had reduced mean relative abundance of Clostridium cluster XIVa (P=0.044) and Akkermansia (P=0.033) and an increase in Bacillaceae (P=0.048) and Fusobacterium (P=0.048). Conclusions: Gut microbiota of CD children at disease onset is different from that of HC. Pro-inflammatory microbiota imbalances were associated with CD symptoms. Further studies are needed to assess whether dysbiosis is associated with CD early onset and symptoms. |
| Databáze: | OpenAIRE |
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