Effective Drug Delivery, In Vitro and In Vivo, by Carbon-Based Nanovectors Noncovalently Loaded with Unmodified Paclitaxel

Autor:	Suzanne L. Craig, Hai T. Tran, James M. Tour, Jacob M. Berlin, Dmitry V. Kosynkin, Ashley D. Leonard, Daniela C. Marcano, Daisuke Sano, Shayou Yan, Rebecca M. Lucente-Schultz, Stefania Fiorentino, Xiaoxia Wen, M. Gabriela Raso, Zvonimir L. Milas, B. Katherine Price, Tam T. Pham, Jeffrey N. Myers
Rok vydání:	2010
Předmět:	Male Drug Biodistribution Materials science Paclitaxel media_common.quotation_subject chemistry.chemical_element General Physics and Astronomy Nanotechnology Pharmacology Article Polyethylene Glycols Mice chemistry.chemical_compound Drug Stability In vivo Cell Line Tumor Nano Animals Humans Tissue Distribution General Materials Science Particle Size neoplasms media_common Drug Carriers Mice Inbred BALB C General Engineering Carbon digestive system diseases In vitro Nanostructures chemistry Drug delivery Toxicity Drug carrier Hydrophobic and Hydrophilic Interactions
Zdroj:	ACS Nano. 4:4621-4636
ISSN:	1936-086X 1936-0851
DOI:	10.1021/nn100975c
Popis:	Many new drugs have low aqueous solubility and high therapeutic efficacy. Paclitaxel (PTX) is a classic example of this type of compound. Here we show that extremely small (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe94f39382cff680f2561d977b89c6d https://doi.org/10.1021/nn100975c Zobrazit plný text záznamu