Utilization of Cobalamin is Ubiquitous in Early-Branching Fungal Phyla
| Autor: | Anna Muszewska, Malgorzata Orlowska, Kamil Steczkiewicz |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
AcademicSubjects/SCI01140
ved/biology.organism_classification_rank.species Cobalamin Cofactor Fungal Proteins 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine hemic and lymphatic diseases Genetics polycyclic compounds heterocyclic compounds Model organism Dikarya early-diverging fungi fungal evolution Gene Ecology Evolution Behavior and Systematics Phylogeny 030304 developmental biology chemistry.chemical_classification 0303 health sciences integumentary system biology Phylogenetic tree Phylum ved/biology AcademicSubjects/SCI01130 Fungi nutritional and metabolic diseases vitamin B12 biology.organism_classification Enzymes Vitamin B 12 Metabolic pathway Enzyme chemistry biology.protein metabolic traits Genome Fungal 030217 neurology & neurosurgery Metabolic Networks and Pathways Research Article |
| Zdroj: | Genome Biology and Evolution |
| ISSN: | 1556-5068 |
| DOI: | 10.2139/ssrn.3732362 |
| Popis: | Cobalamin is a cofactor present in essential metabolic pathways in animals and one of the water-soluble vitamins. It is a complex compound synthesized solely by prokaryotes. Cobalamin dependence is scattered across the tree of life. In particular, fungi and plants were deemed devoid of cobalamin. We demonstrate that cobalamin is utilized by all fungal lineages, except for Dikarya. This observation is supported by the genomic presence of both B12 dependent enzymes and cobalamin modifying enzymes. Moreover, the genes identified are actively transcribed in many taxa. Most fungal cobalamin dependent enzymes and cobalamin metabolism proteins are highly similar to their animal homologs. Phylogenetic analyses support a scenario of vertical inheritance of the cobalamin trait with several losses. Cobalamin usage was probably lost in Mucorinae and at the base of Dikarya which groups most of the model organisms which hindered B12-dependent metabolism discovery in fungi. Our results indicate that cobalamin dependence was a widely distributed trait at least in Opisthokonta, across diverse microbial eukaryotes and likely in the LECA. |
| Databáze: | OpenAIRE |
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