Fetal exposure to lead during pregnancy and the risk of preterm and early-term deliveries
| Autor: | Lu Cheng, Zhongqiang Cao, Wenyu Liu, Wei Xia, Jiaqiang Liao, Wenqian Huo, Bin Zhang, Shunqing Xu, Yuanyuan Li |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
medicine.medical_specialty Pediatrics 010501 environmental sciences Logistic regression 01 natural sciences 03 medical and health sciences Young Adult 0302 clinical medicine Pregnancy medicine Odds Ratio Humans 030212 general & internal medicine Young adult Maternal-Fetal Exchange 0105 earth and related environmental sciences Fetus Obstetrics business.industry Confounding Public Health Environmental and Occupational Health Odds ratio medicine.disease Lead Premature birth Maternal Exposure Cohort Premature Birth Environmental Pollutants Female business |
| Zdroj: | International journal of hygiene and environmental health. 220(6) |
| ISSN: | 1618-131X |
| Popis: | Studies have reported the association between lead exposure during pregnancy and preterm birth. However, findings are still inconsistent. This prospective birth cohort study evaluated the risks of preterm and early-term births and its association with prenatal lead exposure in Hubei, China. A total of 7299 pregnant women were selected from the Healthy Baby Cohort. Maternal urinary lead levels were measured by the Inductively Coupled Plasma Mass Spectrometry. The associations between tertiles of urinary lead levels and the risks of preterm and early-term deliveries were assessed using multiple logistic regression models. The geometric mean of creatinine-adjusted urinary lead concentrations among all participating mothers, preterm birth, and early-term birth were 3.19, 3.68, and 3.17μg/g creatinine, respectively. A significant increase in the risk of preterm births was associated with the highest urinary lead tertile after adjusting for confounders with odds ratio (OR) of 1.96. The association was more pronounced among 25-36 years old mothers with OR of 2.03. Though significant p trends were observed between lead exposure (medium and high tertiles) and the risk of early-term births, their ORs were not significant. Our findings indicate that the risk of preterm birth might increase with higher fetal lead exposure, particularly among women between the age of 25 and 36 years. |
| Databáze: | OpenAIRE |
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