Circadian clock mechanism driving mammalian photoperiodism
| Autor: | Helen C. Christian, Andrew S. I. Loudon, Matthew Hindle, Yasutaka Mizoro, Dave Burt, Ben Saer, Shona H. Wood, Judith McNeilly, Alan S. McNeilly, Yung Sung Cheng, Katarzyna Miedzinska, Simone Meddle, Nicola Begley |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Molecular biology Physiology Circadian clock General Physics and Astronomy 02 engineering and technology Epigenesis Genetic lcsh:Science skin and connective tissue diseases Melatonin photoperiodism Multidisciplinary ARNTL Transcription Factors 021001 nanoscience & nanotechnology Cell biology DNA-Binding Proteins Pituitary Gland Seasons Pars tuberalis 0210 nano-technology hormones hormone substitutes and hormone antagonists medicine.drug endocrine system Photoperiod Science Biology Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Rhythm Circadian Clocks VDP::Mathematics and natural science: 400::Zoology and botany: 480 medicine Animals Circadian rhythm Transcription factor Sheep Mechanism (biology) General Chemistry 030104 developmental biology Gene Expression Regulation lcsh:Q Timer sense organs Zoology VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480 Neuroscience |
| Zdroj: | Wood, S, Hindle, M, Mizoro, Y, Cheng, Y, Saer, B, Miedzinska-Bielecka, K, Christian, H, Begley, N, J, M, McNeilly, A, Meddle, S, Burt, D & Loudon, A 2020, ' Circadian clock mechanism driving mammalian photoperiodism. ', Nature Communications, vol. 11, 4291 (2020), pp. 1-15 . https://doi.org/10.1038/s41467-020-18061-z Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020) Nature Communications Wood, S, Hindle, M M, Mizoro, Y, Cheng, Y, Saer, B, Miedzinska, K, Christian, H C, Begley, N, McNeilly, J, McNeilly, A S, Meddle, S L, Burt, D W & Loudon, A 2020, ' Circadian clock mechanism driving mammalian photoperiodism ', Nature Communications, vol. 11, 4291 . https://doi.org/10.1038/s41467-020-18061-z |
| Popis: | The annual photoperiod cycle provides the critical environmental cue synchronizing rhythms of life in seasonal habitats. In 1936, Bünning proposed a circadian-based coincidence timer for photoperiodic synchronization in plants. Formal studies support the universality of this so-called coincidence timer, but we lack understanding of the mechanisms involved. Here we show in mammals that long photoperiods induce the circadian transcription factor BMAL2, in the pars tuberalis of the pituitary, and triggers summer biology through the eyes absent/thyrotrophin (EYA3/TSH) pathway. Conversely, long-duration melatonin signals on short photoperiods induce circadian repressors including DEC1, suppressing BMAL2 and the EYA3/TSH pathway, triggering winter biology. These actions are associated with progressive genome-wide changes in chromatin state, elaborating the effect of the circadian coincidence timer. Hence, circadian clock-pituitary epigenetic pathway interactions form the basis of the mammalian coincidence timer mechanism. Our results constitute a blueprint for circadian-based seasonal timekeeping in vertebrates. “Life in a seasonal environment requires appropriate timing of physiological changes to survive, but how the circadian clockwork times these changes remains unclear. Here the authors show that the circadian clock genes BMAL2 and DEC1, in concert with epigenetic pathways in the pituitary, have a central role in seasonal timekeeping in mammals.” |
| Databáze: | OpenAIRE |
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