Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease
| Autor: | Shafqat Ahmad, Christina M Astley, Ruth J. F. Loos, Evangelos Evangelou, M. Fabiola Del Greco, Barbara McKnight, Helen R. Warren, Sonja I. Berndt, Carolina Medina-Gomez, Eirini Marouli, Jana V. van Vliet-Ostaptchouk, Joel N. Hirschhorn, Panos Deloukas, Zhihong Zhu, Mark J. Caulfield, Zoltán Kutalik, Jian Yang |
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| Přispěvatelé: | Center for Liver, Digestive and Metabolic Diseases (CLDM), Epidemiology, Internal Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
SELECTION Vital capacity Heart disease endocrine system diseases Vital Capacity Medicine (miscellaneous) Type 2 diabetes Coronary Artery Disease Body Mass Index Coronary artery disease Cohort Studies 0302 clinical medicine Risk Factors Forced Expiratory Volume Medicine 030212 general & internal medicine Lung lcsh:QH301-705.5 2. Zero hunger RISK 0303 health sciences ASSOCIATION Middle Aged MULTIPLE GENETIC-VARIANTS BIAS Cardiology Female General Agricultural and Biological Sciences Medical Genetics Adult medicine.medical_specialty Genotype HEART-DISEASE Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences FEV1/FVC ratio Diabetes mellitus Internal medicine INSTRUMENTAL VARIABLES Humans 030304 developmental biology Aged Medicinsk genetik business.industry MORTALITY nutritional and metabolic diseases Mendelian Randomization Analysis medicine.disease Body Height United Kingdom Blood pressure Diabetes Mellitus Type 2 lcsh:Biology (General) ATHEROSCLEROSIS PLEIOTROPY business Body mass index |
| Zdroj: | Communications Biology, Vol 2, Iss 1, Pp 1-9 (2019) Communications biology, 2:119. Nature Publishing Group Communications Biology Communications biology, vol. 2, pp. 119 Communications Biology, 2:119. Springer Nature |
| ISSN: | 2399-3642 |
| DOI: | 10.1038/s42003-019-0361-2 |
| Popis: | There is evidence that lower height is associated with a higher risk of coronary artery disease (CAD) and increased risk of type 2 diabetes (T2D). It is not clear though whether these associations are causal, direct or mediated by other factors. Here we show that one standard deviation higher genetically determined height (~6.5 cm) is causally associated with a 16% decrease in CAD risk (OR = 0.84, 95% CI 0.80–0.87). This causal association remains after performing sensitivity analyses relaxing pleiotropy assumptions. The causal effect of height on CAD risk is reduced by 1–3% after adjustment for potential mediators (lipids, blood pressure, glycaemic traits, body mass index, socio-economic status). In contrast, our data suggest that lung function (measured by forced expiratory volume [FEV1] and forced vital capacity [FVC]) is a mediator of the effect of height on CAD. We observe no direct causal effect of height on the risk of T2D. Eirini Marouli et al. use Mendelian randomisation analyses to investigate the causal relationship between adult height, coronary artery disease (CAD) and type 2 diabetes (T2D) in the UK Biobank. They find that height has a causal effect on CAD, which is mediated by lung function, while there is no direct effect on the risk of T2D. |
| Databáze: | OpenAIRE |
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