Regulation of chronic stress-induced changes in hypothalamic-pituitary-adrenal activity by the basolateral amygdala
| Autor: | Kai Denski, Seema Bhatnagar, Courtenay Vining |
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| Rok vydání: | 2005 |
| Předmět: |
Agonist
Male endocrine system medicine.medical_specialty Hypothalamo-Hypophyseal System Future studies medicine.drug_class Pituitary-Adrenal System General Biochemistry Genetics and Molecular Biology Lesion Rats Sprague-Dawley Hpa activity chemistry.chemical_compound History and Philosophy of Science Adrenocorticotropic Hormone Internal medicine medicine Animals Chronic stress GABA Agonists Muscimol General Neuroscience Stressor Amygdala Rats medicine.anatomical_structure Endocrinology chemistry Chronic Disease medicine.symptom Psychology Stress Psychological Basolateral amygdala |
| Zdroj: | Annals of the New York Academy of Sciences. 1032 |
| ISSN: | 0077-8923 |
| Popis: | Little is known about the role of the basolateral amygdala (BLA) in regulating hypothalamic-pituitary-adrenal (HPA) activity, particularly chronic stress-induced HPA activity. In the current studies, we examined the effects of manipulations of the BLA on HPA responses to the eighth restraint, to novel restraint after repeated cold, or to acute novel restraint alone. Excito- toxic lesions of the BLA, in general, inhibited HPA activity in both acute and chronically stressed animals.To examine the role of the BLA in chronic stress without affecting the response to the first stress, we injected the GABA agonist muscimol to temporarily inactivate the BLA prior to restraint in the same three groups of animals. In contrast to the lesion data, muscimol enhanced the HPA response to acute restraint and to novel restraint after repeated cold, but it did not affect responses to the eighth restraint. These data suggest that the BLA inhibits HPA responses to novel stress but is not important in animals repeatedly exposed to the same stressor. Future studies will focus on the neuro- anatomical substrates of BLA's effects on HPA activity including whether inputs from the pPVTh are important. |
| Databáze: | OpenAIRE |
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