Effects of 5-fluorouridine on modified nucleosides in mouse liver transfer RNA
| Autor: | Kurt Randerath, Grace H. Chiang, Lee Jane W. Lu, Wen-Cheng Tseng |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
Biophysics Guanosine Biology Biochemistry Pseudouridine chemistry.chemical_compound Mice RNA Transfer medicine 5 fluorouridine Animals Molecular Biology Uridine Base Composition Cytidine Nucleosides Cell Biology Adenosine Molecular biology chemistry Liver Transfer RNA Dihydrouridine Chromatography Thin Layer medicine.drug |
| Zdroj: | Biochemical and biophysical research communications. 73(4) |
| ISSN: | 0006-291X |
| Popis: | Administration of the pyrimidine antimetabolite, 5-fluorouridine, to mice was found to cause a marked specific reduction of the amounts of 5-methyluridine, pseudouridine, and dihydrouridine but not of 3-(3-amino-3-carboxypropyl)uridine in tRNA from the livers of the treated animals. The data presented indicate that this effect is not simply due to the incorporation of 5-fluorouridine into tRNA; the drug appears to interfere directly with the enzymic reactions involved in the modification of the 5-position of uridine. 5-Fluorouridine was found to have no effect on the modification of adenosine, guanosine, and cytidine in mouse liver tRNA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|