Extracellular Vesicle Proteome of Breast Cancer Patients with and Without Cognitive Impairment Following Anthracycline-based Chemotherapy: An Exploratory Study
Autor: | Meng Wei, Adrian Boey, Charles L. Limoli, Yong Qin Koh, Munjal M. Acharya, Alexandre Chan, Ding Quan Ng, Siu Kwan Sze, Chiu Chin Ng, Han Kiat Ho |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Oncology
medicine.medical_specialty Aging Medicine (General) Anthracycline medicine.medical_treatment cancer-related cognitive impairment Medical Biochemistry and Metabolomics chemotherapy Breast cancer R5-920 Clinical Research Internal medicine Breast Cancer Behavioral and Social Science medicine cancer 2.1 Biological and endogenous factors Aetiology Original Research mass spectrometry Pharmacology Chemotherapy business.industry Biochemistry (medical) Rehabilitation Neurosciences Cancer Cognition Extracellular vesicle Pharmacology and Pharmaceutical Sciences Extracellular vesicles medicine.disease Brain Disorders Synaptic plasticity Proteome Molecular Medicine business |
Zdroj: | Biomarker Insights, Vol 16 (2021) Biomarker Insights |
ISSN: | 1177-2719 |
Popis: | Cognitive impairment due to cancer and its therapy is a major concern among cancer patients and survivors. Extracellular vesicle (EVs) composition altered by cancer and chemotherapy may affect neurological processes such as neuroplasticity, potentially impacting the cognitive abilities of cancer patients and survivors. We investigated the EV proteome of breast cancer patients with and without cognitive impairment following anthracycline-based chemotherapy from longitudinally collected plasma. EVs were cup-shaped and positive for Flotillin-1 and TSG-101. We identified 517 differentially expressed EV proteins between the cognitive impaired and non-impaired groups during and post-chemotherapy. The observed decreased expression of p2X purinoceptor, cofilin-1, ADAM 10, and dynamin-1 in the plasma EVs of the cognitive impaired group may suggest alterations in the mechanisms underlying synaptic plasticity. The reduced expression of tight junction proteins among cognitive-impaired patients may imply weakening of the blood-brain barrier. These EV protein signatures may serve as a fingerprint that underscores the mechanisms underlying cognitive impairment in cancer patients and survivors. |
Databáze: | OpenAIRE |
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