Effects of Spontaneous Ischemia on Aerobic Metabolism of Cortical and Medullary Homogenates of Dog Kidney
| Autor: | Louis A. Toth, Howard M. Randall |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Male
Aging medicine.medical_specialty Time Factors Medullary cavity Cellular respiration Ischemia Biology Kidney Nephrectomy Oxidative Phosphorylation General Biochemistry Genetics and Molecular Biology Phosphates Glutarates Dogs Oxygen Consumption Malate Dehydrogenase Internal medicine medicine Animals O2 consumption Pentobarbital Metabolism medicine.disease Isocitrate Dehydrogenase medicine.anatomical_structure Endocrinology Female |
| Zdroj: | Experimental Biology and Medicine. 135:589-593 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-135-35101 |
| Popis: | SummarySpontaneous ischemia of the kidney has been reported in dogs subsequent to anesthesia and/or surgical trauma. This phenomenon can be characterized as having a differential effect on intrarenal aerobic metabolism. Washed homogenates of cortical and medullary tissue were prepared from nonischemic and ischemic kidneys. The rates of O2 consumption, α-KG utilization, and P1 disappearance were the same in cortical homogenates of ischemic and nonischemic kidneys. Each of these rates was significantly lower in medullary homogenates of ischemic kidneys than in nonischemic kidneys. Cortical homogenates that were stressed secondarily by acute aging had rates of O2 consumption, α-KG utilization, and P1 disappearance that were below that of fresh homogenates. The changes in metabolism cannot be explained by changes that were observed in the activities of MDH and ICDH. |
| Databáze: | OpenAIRE |
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