T1DBase: integration and presentation of complex data for type 1 diabetes research

Autor: Erin M. Hulbert, Victor M Cassen, Neil Walker, Barry C. Healy, David B. Burdick, Daisy Flamez, Geoffrey E. Dolman, James E. Allen, Decio L. Eizirik, Nathan Goodman, Christopher C. Cavnor, Sarah Killcoyne, Linda S. Wicker, Burak Kutlu, John A. Todd, Luc J. Smink, Oliver S. Burren, Ellen C. Adlem, Helen Schuilenburg, Josyf C. Mychaleckyj, Karen F. Friery
Rok vydání: 2007
Předmět:
TISSUE EXPRESSION PROFILES
Physiology
MOUSE
Genome
DISEASE
Presentation
Mice
User-Computer Interface
Diabetes Mellitus
Type 1 -- genetics
0302 clinical medicine
Databases
Genetic
Gene expression
media_common
Complex data type
Genetics
0303 health sciences
Articles
ATLAS
Sciences bio-médicales et agricoles
3. Good health
MAP
Corrigendum
PROJECT
Cell type
BROWSER
Diabetes Mellitus
Type 1 -- metabolism
Pancreas -- metabolism
media_common.quotation_subject
Genomics
Computational biology
Biology
Polymorphism
Single Nucleotide
03 medical and health sciences
medicine
Animals
Humans
GENOME DATABASE
Pancreas
Gene
030304 developmental biology
Type 1 diabetes
Internet
Gene Expression Profiling
Biology and Life Sciences
medicine.disease
Rats
Systems Integration
Gene expression profiling
Diabetes Mellitus
Type 1
Informatics
Nucleic acid
UPDATE
SYSTEM
030215 immunology
Zdroj: Nucleic acids research, 35 (Database issue
Nucleic Acids Research
NUCLEIC ACIDS RESEARCH
ISSN: 1362-4962
0305-1048
Popis: T1DBase (http://T1DBase.org) [Smink et al. (2005) Nucleic Acids Res. 33, D544-D549; Burren et al. (2004) Hum. Genomics, 1, 98-109] is a public website and database that supports the type 1 diabetes (T1D) research community. T1DBase provides a consolidated T1D-oriented view of the complex data world that now confronts medical researchers and enables scientists to navigate from information they know to information that is new to them. Overview pages for genes and markers summarize information for these elements. The Gene Dossier summarizes information for a list of genes. GBrowse [Stein et al. (2002) Genome Res. 10, 1599-1610] displays genes and other features in their genomic context, and Cytoscape [Shannon et al. (2003) Genome Res. 13, 2498-2504] shows genes in the context of interacting proteins and genes. The Beta Cell Gene Atlas shows gene expression in beta cells, islets, and related cell types and lines, and the Tissue Expression Viewer shows expression across other tissues. The Microarray Viewer shows expression from more than 20 array experiments. The Beta Cell Gene Expression Bank contains manually curated gene and pathway annotations for genes expressed in beta cells. T1DMart is a query tool for markers and genotypes. PosterPages are 'home pages' about specific topics or datasets. The key challenge, now and in the future, is to provide powerful informatics capabilities to T1D scientists in a form they can use to enhance their research.
Journal Article
Research Support, Non-U.S. Gov't
info:eu-repo/semantics/published
Databáze: OpenAIRE
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