Diminished rostral anterior cingulate activity in response to threat-related events in posttraumatic stress disorder
| Autor: | Ain Chung, Hyunsoo Khang, Minue J. Kim, In Kyoon Lyoo, Soojeong C. Bae, Sujung J. Yoon, Do Un Jeong, Byung Joo Ham, Jeanyung Chey |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Cingulate cortex medicine.medical_specialty Audiology Affect (psychology) Gyrus Cinguli Severity of Illness Index behavioral disciplines and activities Amygdala Conflict Psychological Life Change Events Stress Disorders Post-Traumatic Neuroimaging Surveys and Questionnaires medicine Humans Psychiatry Biological Psychiatry medicine.diagnostic_test Middle Aged medicine.disease Magnetic Resonance Imaging Diagnostic and Statistical Manual of Mental Disorders Functional imaging Affect Psychiatry and Mental health medicine.anatomical_structure Cerebrovascular Circulation Positron-Emission Tomography Anxiety Female medicine.symptom Functional magnetic resonance imaging Psychology Anxiety disorder |
| Zdroj: | Journal of Psychiatric Research. 42:268-277 |
| ISSN: | 0022-3956 |
| DOI: | 10.1016/j.jpsychires.2007.02.003 |
| Popis: | Background Previous brain imaging studies have reported hyperactivation of the amygdala and hypoactivation of the anterior cingulate in posttraumatic stress disorder (PTSD) patients, which is believed to be an underlying neural mechanism of the PTSD symptoms. The current study specifically focuses on the abnormal activity of the rostral anterior cingulate, using a paradigm which elicits an unexpected processing conflict caused by salient emotional stimuli. Methods Twelve survivors (seven men and five women) of the Taegu subway fire in 2003, who later developed PTSD, agreed to participate in this study. Twelve healthy volunteers (seven men and five women) were recruited for comparison. Functional brain images of all participants were acquired using functional magnetic resonance imaging while performing a same–different judgment task, which was modified to elicit an unexpected emotional processing conflict. Results PTSD patients, compared to comparison subjects, showed a decreased rostral anterior cingulate functioning when exposed to situations which induce an unexpected emotional processing conflict. Moreover, PTSD symptom severity was negatively correlated to the level of decrease in the rostral anterior cingulate activity. Conclusions The results of this study provide evidence that the rostral anterior cingulate functioning is impaired in PTSD patients during response-conflict situations that involve emotional stimuli. |
| Databáze: | OpenAIRE |
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