Restoration of plakoglobin expression in bladder carcinoma cell lines suppresses cell migration and tumorigenic potential
| Autor: | Summerhayes Ic, O Durrani, Kimberly M. Rieger-Christ, Robert S. Hanley, John A. Libertino, H Ma, Amy S. Yee, Linda Ng |
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| Rok vydání: | 2005 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Down-Regulation Gene Expression Plakoglobin Biology Transfection medicine.disease_cause Cell Line Mice Cell Movement Desmosome Cell Line Tumor medicine Animals Humans Gene silencing Genes Tumor Suppressor Neoplasm Invasiveness Gene Silencing signalling Neoplasm Staging Gene knockdown Desmoglein 2 Bladder cancer Cell migration Cadherins medicine.disease Wnt Proteins Cytoskeletal Proteins medicine.anatomical_structure Desmoplakins Urinary Bladder Neoplasms Oncology plakoglobin Catenin Models Animal Disease Progression Cancer research Intercellular Signaling Peptides and Proteins bladder cancer gamma Catenin desmosome Desmogleins Translational Therapeutics Carcinogenesis Signal Transduction |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | The reduction or loss of plakoglobin expression in late-stage bladder cancer has been correlated with poor survival where upregulation of this catenin member by histone deacetylase inhibitors has been shown to accompany tumour suppression in an in vivo model. In this study, we directly addressed the question of the role of plakoglobin in bladder tumorigenesis following restoration, or knockdown of expression in bladder carcinoma cell lines. Restoration of plakoglobin expression resulted in a reduction in migration and suppression of tumorigenic potential in vivo. Immunocytochemistry revealed cytoplasmic and membranous localisation of plakoglobin in transfectants with |
| Databáze: | OpenAIRE |
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