Chemoselective Activation of Diethyl Phosphonates: Modular Synthesis of Biologically Relevant Phosphonylated Scaffolds
| Autor: | Nuno Maulide, Jörg Heider, Pauline Adler, Amandine Pons, Bogdan R. Brutiu, Jing Li |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Biological Products
Sulfonamides phosphonamidates Selective reaction triflic anhydride 010405 organic chemistry Chemistry Communication Organophosphonates General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Communications Catalysis 0104 chemical sciences Nucleophile Alkynes Biological property Nitriles Phosphonates Amines Furans phosphinates phosphonothioates |
| Zdroj: | Angewandte Chemie (International Ed. in English) Angewandte Chemie International Edition |
| ISSN: | 1521-3773 1433-7851 |
| Popis: | Phosphonates have garnered considerable attention for years owing to both their singular biological properties and their synthetic potential. State‐of‐the‐art methods for the preparation of mixed phosphonates, phosphonamidates, phosphonothioates, and phosphinates rely on harsh and poorly selective reaction conditions. We report herein a mild method for the modular preparation of phosphonylated derivatives, several of which exhibit interesting biological activities, that is based on chemoselective activation with triflic anhydride. This procedure enables flexible and even iterative substitution with a broad range of O, S, N, and C nucleophiles. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text