Separation of the enantiomeric intermediates of some platelet-activating factor analogues on a naphthylalanine-type Pirkle column
| Autor: | R. Webster, David H. Thompson, E. Geiger, P.L. Camacho, Gy. Vigh |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Chromatography
Alanine Platelet-activating factor Chemistry Organic Chemistry Stereoisomerism Ether General Medicine Biochemistry Analytical Chemistry Chiral selectivity chemistry.chemical_compound Glycerol Separation method Organic chemistry Platelet Activating Factor Enantiomer Chiral derivatizing agent |
| Zdroj: | Journal of Chromatography A. 506:611-616 |
| ISSN: | 0021-9673 |
| DOI: | 10.1016/s0021-9673(01)91609-7 |
| Popis: | A chiral high-performance liquid-chromatographic separation method was developed for the analysis of some glycerol-based, ether-linked platelet-activating factor precursors. Using a d -naphthylalanine-type Pirkle-column and tetrahydrofuran—hexane eluents, the retention—structure relationships were determined for a large number of glycerol ether derivatives. The derivatives leading to the highest chiral selectivity factors in the analytical separations were surveyed for their applicability in large-scale isolation of chiral synthetic intermediates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|