Defining a critical period for inhibitory circuits within the somatosensory cortex
Autor: | Judy Sng, George J. Augustine, Shun Qiang Lo |
---|---|
Přispěvatelé: | Lee Kong Chian School of Medicine (LKCMedicine) |
Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Patch-Clamp Techniques Science Period (gene) Mice Transgenic Sensory system Optogenetics Neural Circuits Inhibitory postsynaptic potential Somatosensory system Article Mice 03 medical and health sciences 0302 clinical medicine Genes Reporter Interneurons Biological neural network Animals Neuronal Plasticity Multidisciplinary biology Pyramidal Cells Somatosensory Cortex Barrel cortex Electrophysiological Phenomena Parvalbumins 030104 developmental biology biology.protein Medicine Barrel Cortex Neuroscience Biomarkers 030217 neurology & neurosurgery Parvalbumin |
Zdroj: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017) |
Popis: | Although experience-dependent changes in brain inhibitory circuits are thought to play a key role during the “critical period” of brain development, the nature and timing of these changes are poorly understood. We examined the role of sensory experience in sculpting an inhibitory circuit in the primary somatosensory cortex (S1) of mice by using optogenetics to map the connections between parvalbumin (PV) expressing interneurons and layer 2/3 pyramidal cells. Unilateral whisker deprivation decreased the strength and spatial range of inhibitory input provided to pyramidal neurons by PV interneurons in layers 2/3, 4 and 5. By varying the time when sensory input was removed, we determined that the critical period closes around postnatal day 14. This yields the first precise time course of critical period plasticity for an inhibitory circuit. NRF (Natl Research Foundation, S’pore) ASTAR (Agency for Sci., Tech. and Research, S’pore) Published version |
Databáze: | OpenAIRE |
Externí odkaz: |