Role of dietary fat on obesity-related postmenopausal breast cancer: insights from mouse models and methodological considerations
| Autor: | Pei Yee Tan, Kim Tiu Teng |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Breast Neoplasms Study duration Mice 03 medical and health sciences 0302 clinical medicine Breast cancer Animal model Breast cancer cell line Risk Factors Surgical oncology Internal medicine medicine Animals Humans Pharmacology (medical) Radiology Nuclear Medicine and imaging Obesity skin and connective tissue diseases Dietary fat business.industry General Medicine medicine.disease Dietary Fats Postmenopause Disease Models Animal 030104 developmental biology 030220 oncology & carcinogenesis Female business |
| Zdroj: | Breast Cancer. 28:556-571 |
| ISSN: | 1880-4233 1340-6868 |
| DOI: | 10.1007/s12282-021-01233-0 |
| Popis: | The increasing incidence rate of breast cancer in the last few decades is known to be linked to the upward trend of obesity prevalence worldwide. The consumption of high-fat diet in particular has been correlated with postmenopausal breast cancer risk. The underlying mechanisms, using suitable and reliable experimental mouse model, however, is lacking. The current review aims to discuss the evidence available from mouse models on the effects of dietary fats intake on postmenopausal breast cancer. We will further discuss the biochemical mechanisms involved in the occurrence of postmenopausal breast cancer. In addition, the methodological considerations and their limitations in obesity-related postmenopausal breast cancer, such as choice of mouse models and breast cancer cell lines as well as the study duration will be reviewed. The current review will provide a platform for further development of new xenograft models which may offer the opportunity to investigate the mechanisms of postmenopausal breast cancer in a greater detail. |
| Databáze: | OpenAIRE |
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