Lipidomics reveals multiple pathway effects of a multi-components preparation on lipid biochemistry in ApoE*3Leiden.CETP mice
| Autor: | Thomas Hankemeier, Mei Wang, Jildau Bouwman, Marco Vennik, Guowang Xu, Suzan Wopereis, Jan van der Greef, Raymond Ramaker, Anita M. van den Hoek, Henrie A. A. J. Korthout, Chunxiu Hu, Renger F. Witkamp, Heng Wei, Theo H. Reijmers, Louis M. Havekes, Elwin Verheij |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Apolipoprotein E
Apolipoprotein B hdl-cholesterol Apolipoprotein E3 Drug Evaluation Preclinical lcsh:Medicine Biomedical Innovation Pharmacology Cardiovascular Biochemistry Analytical Chemistry chemistry.chemical_compound Mice Rimonabant Piperidines Life Adipocytes lcsh:Science Chromatography Multidisciplinary biology Anticholesteremic Agents apoe-asterisk-3-leiden.cetp mice systems biology Animal Models cholesteryl ester transfer Lipids Nutritional Biology PRI Biometris Chemistry Medicine Female lipids (amino acids peptides and proteins) EELS - Earth Environmental and Life Sciences Healthy Living Niacin Metabolic Networks and Pathways medicine.drug Research Article transfer protein Health Pharmacology chinese medicine Mice Transgenic transgenic mice weight-reduction Model Organisms Chemical Analysis Complementary and Alternative Medicine 3T3-L1 Cells Lipidomics Cholesterylester transfer protein Chemical Biology medicine Animals Metabolomics Biology Nutrition VLAG Cholesterol lcsh:R Body Weight MHR - Metabolic Health Research MSB - Microbiology and Systems Biology RAPID - Risk Analysis for Products in Development Lipid metabolism Lipid Metabolism overweight patients aggravates atherosclerosis Cholesterol Ester Transfer Proteins Metabolism chemistry Metabolic Disorders biology.protein Pyrazoles lcsh:Q Medicinal Chemistry Drugs Chinese Herbal |
| Zdroj: | PLoS ONE, 7(1), e30332 PLoS ONE, 1, 7 PLoS ONE, 7(1) PLoS ONE 7 (2012) 1 PLoS ONE PLoS ONE, Vol 7, Iss 1, p e30332 (2012) |
| ISSN: | 1932-6203 |
| Popis: | BACKGROUND: Causes and consequences of the complex changes in lipids occurring in the metabolic syndrome are only partly understood. Several interconnected processes are deteriorating, which implies that multi-target approaches might be more successful than strategies based on a limited number of surrogate markers. Preparations from Chinese Medicine (CM) systems have been handed down with documented clinical features similar as metabolic syndrome, which might help developing new intervention for metabolic syndrome. The progress in systems biology and specific animal models created possibilities to assess the effects of such preparations. Here we report the plasma and liver lipidomics results of the intervention effects of a preparation SUB885C in apolipoprotein E3 Leiden cholesteryl ester transfer protein (ApoE*3Leiden.CETP) mice. SUB885C was developed according to the principles of CM for treatment of metabolic syndrome. The cannabinoid receptor type 1 blocker rimonabant was included as a general control for the evaluation of weight and metabolic responses. METHODOLOGY/PRINCIPAL FINDINGS: ApoE*3Leiden.CETP mice with mild hypercholesterolemia were divided into SUB885C-, rimonabant- and non-treated control groups. SUB885C caused no weight loss, but significantly reduced plasma cholesterol (-49%, p CONCLUSIONS: SUB885C, a multi-components preparation, is able to produce anti-atherogenic changes in lipids of the ApoE*3Leiden.CETP mice, which are comparable to those obtained with compounds belonging to known drugs (e.g. rimonabant, atorvastatin, niacin). This study successfully illustrated the power of lipidomics in unraveling intervention effects and to help finding new targets or ingredients for lifestyle-related metabolic abnormality |
| Databáze: | OpenAIRE |
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