The Efficacy of Orgotein in the Treatment of Acute Toxicity Due to Radiotherapy on Head and Neck Tumors
| Autor: | Ignacio Alvarez, Angel Urpegui, Ricardo Esco, Carmen Velilla, Sonia Polo, Javier Valencia, M. Angeles Llorens, Pilar Coronel, Natividad Bascón |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Time Factors medicine.medical_treatment Severity of Illness Index 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Metalloproteins medicine Mucositis Humans Radiation Injuries Aged Retrospective Studies Aged 80 and over Inflammation Chemotherapy Radiotherapy business.industry Anti-Inflammatory Agents Non-Steroidal Head and neck cancer Mouth Mucosa General Medicine Middle Aged medicine.disease Dysphagia Acute toxicity Discontinuation Surgery Radiation therapy Logistic Models Treatment Outcome Oncology Head and Neck Neoplasms 030220 oncology & carcinogenesis Toxicity medicine.symptom business |
| Zdroj: | Tumori Journal. 88:385-389 |
| ISSN: | 2038-2529 0300-8916 |
| DOI: | 10.1177/030089160208800507 |
| Popis: | Aims and background To assess the efficacy of orgotein in the treatment of acute secondary effects of radiotherapy on head and neck tumors. Material and methods Data were collected on 41 patients who received radiotherapy for tumors of the head and neck. Radiotherapy was the exclusive treatment in 19.5% of cases, with surgery in 24.4%, chemotherapy in 48.8%, and with both in 7.3%. The toxicity requiring use of orgotein was: oropharynx mucositis (26.8%), dysphagia (34.2%), or both (39%), in grade 2 or more according to the RTOG scale. Orgotein (8 mg im) was administered every 48 hrs until radiotherapy was finished. Results The overall response rate was 92.5%; a complete response was obtained in 12 patients (30%) and partial in 25 (62.5%). The reduction in toxicity at the end of radiotherapy was one grade in 18 patients (45%), 2 grades in 16 (40%), 3 in 2 patients (5%), and 4 grades in the only patient with grade 4 acute toxicity. A statistically significant influence was shown in obtaining complete response: laryngeal tumor location (P = 0.037), duration of radiotherapy of more than 53 days (P = 0.002), discontinuation for non-toxic reasons (P = 0.008). Conclusions We consider that orgotein is highly effective in dealing with acute secondary effects of radiotherapy on the head and neck area. |
| Databáze: | OpenAIRE |
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