Peripheral blood B-cell death compensates for excessive proliferation in lymphoid tissues and maintains homeostasis in bovine leukemia virus-infected sheep
| Autor: | Michel Bonneau, Geneviève Jean, Nicolas Gillet, Arnaud Florins, Pierre Kerkhofs, Lucas Willems, Christophe Debacq, Richard Kettmann, Mathieu Boxus, André Thewis, Becca Asquith, Jack Hay, Maria Teresa Sanchez-Alcaraz, Isabelle Schwartz-Cornil |
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| Přispěvatelé: | Fonds national de la recherche scientifique, Department of Immunology, Imperial College London, Department of Medical Genetics and Microbiology, University of Toronto, Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Institut National de la Recherche Agronomique (INRA), Sciensano [Bruxelles], Réseau International des Instituts Pasteur (RIIP) |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Lymphoid Tissue
Lymphocyte Immunology Sheep Diseases Succinimides Biology Carboxyfluorescein diacetate succinimidyl ester Microbiology Blood cell 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine B cell homeostasis Cell Movement Virology Lymphocyte homeostasis medicine Leukemia Virus Bovine Animals Homeostasis Peripheral blood cell B cell 030304 developmental biology Cell Proliferation 0303 health sciences B-Lymphocytes CD11b Antigen Deltaretrovirus Infections Sheep Bovine leukemia virus Cell Death biology.organism_classification Fluoresceins Kinetics medicine.anatomical_structure chemistry Insect Science [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Pathogenesis and Immunity 030215 immunology |
| Zdroj: | Journal of Virology Journal of Virology, American Society for Microbiology, 2006, 80 (19), pp.9710-9719. ⟨10.1128/JVI.01022-06⟩ |
| ISSN: | 0022-538X 1098-5514 |
| Popis: | The size of a lymphocyte population is primarily determined by a dynamic equilibrium between cell proliferation and death. Hence, lymphocyte recirculation between the peripheral blood and lymphoid tissues is a key determinant in the maintenance of cell homeostasis. Insights into these mechanisms can be gathered from large-animal models, where lymphatic cannulation from individual lymph nodes is possible. In this study, we assessed in vivo lymphocyte trafficking in bovine leukemia virus (BLV)-infected sheep. With a carboxyfluorescein diacetate succinimidyl ester labeling technique, we demonstrate that the dynamics of lymphocyte recirculation is unaltered but that accelerated proliferation in the lymphoid tissues is compensated for by increased death in the peripheral blood cell population. Lymphocyte homeostasis is thus maintained by biphasic kinetics in two distinct tissues, emphasizing a very dynamic process during BLV infection. |
| Databáze: | OpenAIRE |
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