Locus coeruleus-norepinephrine: basic functions and insights into Parkinson’s disease
| Autor: | Katharina Schmidt, Bilal A. Bari, Varun Chokshi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
endocrine system Parkinson's disease catecholamines copper neurodegenerative diseases neuromodulation neuronal circuits neuropsychiatric symptoms noradrenaline synaptic plasticity Disease Review lcsh:RC346-429 03 medical and health sciences Norepinephrine 0302 clinical medicine Developmental Neuroscience Neuromodulation Medicine lcsh:Neurology. Diseases of the nervous system business.industry musculoskeletal neural and ocular physiology Pontine nuclei medicine.disease 030104 developmental biology medicine.anatomical_structure Neuronal circuits nervous system Synaptic plasticity behavior and behavior mechanisms Locus coeruleus business Neuroscience 030217 neurology & neurosurgery psychological phenomena and processes medicine.drug |
| Zdroj: | Neural Regeneration Research, Vol 15, Iss 6, Pp 1006-1013 (2020) Neural Regeneration Research |
| ISSN: | 1673-5374 |
| Popis: | The locus coeruleus is a pontine nucleus that produces much of the brain’s norepinephrine. Despite its small size, the locus coeruleus is critical for a myriad of functions and is involved in many neurodegenerative and neuropsychiatric disorders. In this review, we discuss the physiology and anatomy of the locus coeruleus system and focus on norepinephrine’s role in synaptic plasticity. We highlight Parkinson’s disease as a disorder with motor and neuropsychiatric symptoms that may be understood as aberrations in the normal functions of locus coeruleus. |
| Databáze: | OpenAIRE |
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