Therapeutic potential of curcumin in eye diseases
| Autor: | Piotr Skopiński, Anna Dąbrowska, Agata Góźdź, Anna Hyc, Anna Osiecka-Iwan, Dorota M. Radomska-Leśniewska |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
genetic structures
Eye disease Immunology eye disease lcsh:Medicine Traditional Chinese medicine Disease Pharmacology 03 medical and health sciences chemistry.chemical_compound angiogenesis 0302 clinical medicine age-related macular degeneration (amd) medicine conjunctivitis Immunology and Allergy curcumin reactive oxygen species (ros) Review Paper business.industry lcsh:R Diabetic retinopathy Macular degeneration medicine.disease eye diseases diabetic retinopathy glaucoma chemistry cataract Corneal neovascularization Curcumin Eye disorder sense organs business 030215 immunology |
| Zdroj: | Central European Journal of Immunology, Vol 44, Iss 2, Pp 181-189 (2019) Central-European Journal of Immunology |
| ISSN: | 1644-4124 1426-3912 |
| Popis: | Curcumin (diferuloylmethane) derived from the rhizome of Curcuma longa L. has been used for thousands of years in traditional Chinese medicine and Ayurvedic medicine in Asian countries to treat liver diseases, rheumatoid diseases, diabetes, atherosclerosis, infectious diseases and cancer. It exhibits a wide range of pharmacological properties, which include antioxidant, anti-inflammatory, antimutagenic, antimicrobial and anticancer activity. Herein the mechanisms of curcumin impact on oxidative stress, angiogenesis and inflammatory processes are described indicating that curcumin use may inhibit those pathological conditions and restore body homeostasis. Its effectiveness was also proved for major eye diseases. In this review, the influence of curcumin on eye diseases, such as glaucoma, cataract, age-related macular degeneration, diabetic retinopathy, corneal neovascularization, corneal wound healing, dry eye disease, conjunctivitis, pterygium, anterior uveitis are reported. The analysis of a number of clinical and preclinical investigations indicates that curcumin may be used as a therapeutic agent in the treatment of various eye disorders. |
| Databáze: | OpenAIRE |
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