Value of 68Ga-PSMA HBED-CC PET for the Assessment of Lymph Node Metastases in Prostate Cancer Patients with Biochemical Recurrence: Comparison with Histopathology After Salvage Lymphadenectomy
| Autor: | Ambros J. Beer, Markus Schwaiger, Tobias Maurer, Juergen E. Gschwend, Frank-Philipp Graner, Bernhard Haller, Gregor Weirich, Isabel Rauscher, Alan Doherty, Matthias Eiber |
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| Rok vydání: | 2016 |
| Předmět: |
Biochemical recurrence
Adult Male medicine.medical_specialty medicine.medical_treatment Biopsy Salvage therapy Gallium Radioisotopes Sensitivity and Specificity 030218 nuclear medicine & medical imaging 03 medical and health sciences Prostate cancer 0302 clinical medicine medicine Organometallic Compounds Humans Radiology Nuclear Medicine and imaging Lymph node Edetic Acid Gallium Isotopes Aged Retrospective Studies Salvage Therapy medicine.diagnostic_test business.industry Prostatic Neoplasms Reproducibility of Results Magnetic resonance imaging Middle Aged medicine.disease medicine.anatomical_structure Treatment Outcome Positron emission tomography 030220 oncology & carcinogenesis Lymphatic Metastasis Positron-Emission Tomography Lymph Node Excision Histopathology Lymphadenectomy Radiology Lymph Nodes Neoplasm Recurrence Local Radiopharmaceuticals business Oligopeptides |
| Zdroj: | Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 57(11) |
| ISSN: | 1535-5667 |
| Popis: | The purpose of this study was to evaluate the accuracy of Glu-NH-CO-NH-Lys-(Ahx)-[68Ga(HBED-CC)] PET compared with morphologic imaging for the assessment of lymph node metastases (LNM) in patients with recurrent prostate cancer. Methods: Forty-eight patients (median age, 71 y; interquartile range, 66–74 y) with biochemical recurrence (median prostate-specific antigen level, 1.31 ng/mL; interquartile range, 0.75–2.55 ng/mL) who underwent 68Ga–prostate-specific membrane antigen (PSMA) HBED-CC PET/CT or PET/MR and salvage lymphadenectomy were retrospectively included. Institutional review board approval and written informed consent were obtained from all patients for the purpose of anonymized evaluation and publication of their data. Standardized predefined lymph node (LN) template fields (n = 10) were evaluated in 68Ga-PSMA HBED-CC PET and morphologic imaging for the presence of LNM using a 5-point-scale. Additionally, SUVmean/max and size of suspicious lesions were determined. Specificity of 68Ga-PSMA HBED-CC PET imaging for PET-positive LNs was defined by comparison to histopathology. The diagnostic accuracy of 68Ga-PSMA HBED-CC PET compared with morphologic imaging alone was assessed, and areas under the receiver-operating-characteristic curves are presented. Results: LNM were found histologically in 68 of 179 resected anatomic LN fields (38.0%). The specificity of 68Ga-PSMA HBED-CC PET and morphologic imaging was 97.3% and 99.1%, respectively. However, 68Ga-PSMA HBED-CC PET detected LNM in 53 of 68 histopathologically proven metastatic LN fields (77.9%) whereas morphologic imaging was positive in only 18 of 67 (26.9%). 68Ga-PSMA HBED-CC PET imaging performed significantly superior to morphologic imaging for detection of LNM (difference in the areas under the receiver-operating-characteristic curves, 0.139; 95% confidence interval, 0.063–0.214; P |
| Databáze: | OpenAIRE |
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